SO-730
Chemical Name: 5'-O-[(O-Benzyl-L-alanino)(phenoxy)phosphoryl]-3'-deoxy-2',3'-didehydrothymidine
CAS No. 178469-24-4
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute for Medical Research (Originator)
合成路线:Title phosphoramidate was obtained by condensation of phenyl (benzyloxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
📌 参考资料/链接：
参考文献标题:Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
文献作者:Balzarini,J.; De Clercq,E.; Sheeka,H.M.; Cahard,D.; McGuigan,C.
参考来源:Bioorg Med Chem Lett 1996,6(10),1183
📄 详细内容
合成路线:Title phosphoramidate was obtained by condensation of phenyl [(2-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
合成路线:Title phosphoramidate was obtained by condensation of phenyl (phenoxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
合成路线:Title phosphoramidate was obtained by condensation of phenyl (benzyloxyalanino)phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
合成路线:Title phosphoramidate was obtained by condensation of phenyl [(1-naphthylmethoxy)alanino]phosphorochloridate (I) with 2',3'-dideoxy-2',3'-didehydrothymidine (II) in the presence of N-methylmorpholine in THF at r.t.
参考文献标题:Synthesis,anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T)
文献作者:McGuigan,C.; Sutton,P.W.; Cahard,D.; Turner,K.; O'Leary,G.; Wang,Y.; Gumbleton,M.; De Clercq,E.; Balzarini,J.
参考来源:Antivir Chem Chemother 1998,9(6),473