NK-5807

Chemical Name: (-)-N-[4-(10-Acetamido-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridin-2-yl)-2(S)-(3,4-dichlorophenyl)butyl]-N-methylbenzamide maleate
CAS No. 219536-57-9 (free base), 219536-58-0 (fumarate salt (1:1))
项目整合开发状态: Preclinical
项目研究机构: Nippon Kayaku (Originator)
合成路线:The benzonaphthyridine system (III) was prepared by condensation of 1-Boc-4-piperidone (I) with 2-aminobenzonitrile (II) in the presence of ZnCl2.After acetylation of the 10-amino group of (III) with Ac2O in pyridine to afford (IV),the N-Boc protecting group was removed by treatment with HCl in dioxan-methanol,yielding 10-acetylamino-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine (V).The tricyclic amine (V) was then alkylated with the chiral sulfonate (VI),and the target compound was finally converted to the corresponding fumarate salt.