N-2733
Chemical Name: 1-[3-(3-Pyridinyl)-2(E)-propenoyl]-2-pyrrolidinone hydrochloride
CAS No. 141236-60-4 (free base), 132220-88-3 (undefined isomer, free base)
项目整合开发状态: Preclinical
项目研究机构: Nisshin Pharma (Originator)
合成路线:Treatment of 3-(3-pyridyl)acrylic acid (I) with oxalyl chloride afforded the corresponding acid chloride (II).This was coupled with 1-trimethylsilyl-2-pyrrolidinone (IV) (prepared from pyrrolidinone (III) and hexamethyldisilazane),to produce the target imide.
📌 参考资料/链接：
参考文献标题:Pyrrolidinone derivs.
文献作者:Nagasaka,T.; Yamada,H.; Hamaguchi,F.(Nisshin Flour Milling Co.,Ltd.)
参考来源:JP 1990225458
📄 详细内容
合成路线:Treatment of 3-(3-pyridyl)acrylic acid (I) with oxalyl chloride afforded the corresponding acid chloride (II).This was coupled with 1-trimethylsilyl-2-pyrrolidinone (IV) (prepared from pyrrolidinone (III) and hexamethyldisilazane),to produce the target imide.
参考文献标题:Synthesis of 1-trans-cinnamoyl- and 1-[trans-3-(pyridyl)acryloyl]-2-pyrrolidinone derivatives and their effect on hemicholinium-induced impairment of water maze learning in mice
文献作者:Nagasaka,T.; Momose,K.; Hamaguchi,F.; Yamada,K.; Yamada,H.; Suzuki,Y.
参考来源:Yakugaku Zasshi 1992,112(2),100