新产品编号:76445
Chemical Name: 2,2-Dichloro-N-[2-[3-(1H-indol-3-yl)-2-quinolinylmethyl]phenyl]acetamide
CAS No. 159018-53-8
项目整合开发状态: Preclinical
项目研究机构: Indian Institute of Chemical Biology (Originator)
合成路线:Treatment of an excess of indole (I) with dichloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III),which was cyclized and acylated to yield the title indolyl quinoline.
合成路线:Treatment of an excess of indole (I) with chloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III),which was cyclized and acylated to yield the title indolyl quinoline.
📌 参考资料/链接：
参考文献标题:Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis
文献作者:Chakrabarti,G.; Basu,A.; Manna,P.P.; Mahato,S.B.; Mandal,N.B.; Bandyopadhyay,S.
参考来源:J Antimicrob Chemother 1999,43(3),359
📄 详细内容
合成路线:Treatment of an excess of indole (I) with dichloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III),which was cyclized and acylated to yield the title indolyl quinoline.
合成路线:Treatment of an excess of indole (I) with chloroacetyl chloride (II) in the presence of AlCl3 under Friedel-Crafts conditions produced the trimer intermediate (III),which was cyclized and acylated to yield the title indolyl quinoline.
参考文献标题:Synthesis of indolylquinolines under Friedel-Crafts reaction conditions
文献作者:Mahato,S.B.; et al.
参考来源:Tetrahedron 1994,50(36),10803