VUF-K-8788

Chemical Name: 7-[3-[4-(2-Quinolinylmethyl)-1-piperazinyl]propoxy]-3,4-dihydro-2H-1,4-benzothiazin-3-one
CAS No. 219741-10-3
项目整合开发状态: Preclinical
项目研究机构: Kowa (Originator)
合成路线:The alkylation of N-formylpiperazine (II) with 2-(chloromethyl)quinoline (I) produced the disubstituted piperazine (III).The formyl group of (III) was then cleaved by means of H2SO4 in boiling EtOH,yielding quinolylmethylpiperazine (IV).Subsequent alkylation of (IV) with 1-bromo-3-chloropropane (V) afforded the chloropropyl derivative (VI).This was finally condensed with 7-hydroxybenzothiazinone (VII) in the presence of K2CO3 and a phase-transfer catalyst to furnish the title compound.