项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:478273

Chemical Name: [1R-(1alpha,3abeta,4beta,5alpha,7aalpha)]-2-[5-[5-Cyano-1-methylene-4(Z)-pentenyl]-1-[1(R),5-dimethylhexyl]-7a-methylperhydroinden-4-yl]acetic acid
CAS No. 219579-70-1
项目整合开发状态: B...
参考文献标题:Seco-cholestane derivs.and methods of making the same
文献作者:Peng,H.; Zalkow,L.H.(Georgia Technology Research Corp.)
参考来源:US 6011058

HP-19

Chemical Name: [1R-(1alpha,3abeta,4beta,5alpha,7aalpha)]-2-[5-(5-Cyano-1-methylenepentyl)-1-[1(R),5-dimethylhexyl]-7a-methylperhydroinden-4-yl]acetic acid
CAS No. 219579-76-7
项目整合开发状态: Biologica...
参考文献标题:Seco-cholestane derivs.and methods of making the same
文献作者:Peng,H.; Zalkow,L.H.(Georgia Technology Research Corp.)
参考来源:US 6011058

新产品编号:470363

Chemical Name: (?-(6S*,7R*)-8-Oxo-7-(2-phenylacetamido)-3-(trifluoromethylsulfonyloxy)-1,4-diazabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No. 219118-51-1
项目整合开发状态: Biological Testing
项目研究...
参考文献标题:Syntheses of new isodethiaazacephems as potent antibacterial agents
文献作者:Hwu,J.R.; Tsay,S.-C.; Hakimelahi,S.
参考来源:J Med Chem 1998,41(24),4681

新产品编号:464035

Chemical Name: 1-(4-Bromophenyl)-2-methyl-4,9-dihydro-1H-imidazo[4,5-g]quinoxaline-4,9-dione
CAS No. 218271-09-1
项目整合开发状态: Biological Testing
项目研究机构: Ewha Womans University (Originator), Kore...
参考文献标题:Synthesis and cytotoxicity of 2-methyl-4,9-dihydro-1-substituted-1H-imidazo[4,5-g]quinoxaline-4,9-diones and 2,3-disubstituted-5,10-pyrazino[2,3-g]quinoxalinediones
文献作者:Yoo,H.-W.; Suh,M.-E.; Park,S.W.
参考来源:J Med Chem 1998,41(24),4716

新产品编号:468781

Chemical Name: 2'-Deoxy-2'-(3-methoxybenzamido)-N6-(2-methylbenzyl)adenosine
CAS No. 218924-80-2
项目整合开发状态: Biological Testing
项目研究机构: Howard Hughes Medical Institute (Originator), University ...
参考文献标题:Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design
文献作者:Aronov,A.M.; Verlinde,C.L.; Hol,W.G.; Gelb,M.H.
参考来源:J Med Chem 1998,41(24),4790

新产品编号:462453

Chemical Name: 5-(Benzyloxycarbonylamino)pentanoic acid 3-oxo-2,3-dihydrobenzisothiazol-2-ylmethyl ester S,S-dioxide
CAS No. 218270-47-4
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Or...
参考文献标题:1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase
文献作者:Combrink,K.D.; G黮geze,H.B.; Meanwell,N.A.; Pearce,B.C.; Zulan,P.; Bisacchi,G.S.; Roberts,D.G.; Stanley,P.; Seiler,S.M.
参考来源:J Med Chem 1998,41(24),4854

DPC-963, DMP-963

Chemical Name: 4(S)-(2-Cyclopropylethynyl)-5,6-difluoro-4-(trifluoromethyl)-3,4-dihydro-1H-quinazolin-2-one
CAS No. 214287-90-8
项目整合开发状态: Phase I
项目研究机构: Bristol-Myers Squibb (Originator)
...
参考文献标题:4,4-Disubstd.-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
文献作者:Corbett,J.W.; Ko,S.S.(DuPont Pharmaceuticals Co.)
参考来源:US 6124302; WO 9845276

LJP-920

Chemical Name: 30-[3-O-(alpha-D-Galactopyranosyl)-beta-D-galactopyranosyloxy]-14(S)-[11-[3-O-(alpha-D-galactopyranosyl)-beta-D-galactopyranosyloxy]-6,9-dioxa-3-thiaundecanamido]-2-[28-[3-O-(alpha-D-ga...
参考文献标题:Conjugates comprising galactose alpha 1,3 galactosyl epitopes and methods of using same
文献作者:Yu,L.; Jack,R.M.; Jones,D.(La Jolla Pharmaceutical Co.)
参考来源:EP 1137652; WO 0034296

新产品编号:522569

Chemical Name: N-[2-[N-(5-Methoxy-1,2,3,4-tetrahydronaphth-2-yl)-N-propylamino]ethyl]benzamide hydrochloride
CAS No. 220772-95-2, 220772-98-5 (HCl)
项目整合开发状态: Preclinical
项目研究机构: AstraZeneca (...
参考文献标题:2-Aminotetralin-derived substituted benzamides with mixed dopamine D2,D3,and serotonin 5-HT1A receptor binding properties: A novel class of potential atypical antipsychotic agents
文献作者:Homan,E.J.; Copinga,S.; Elfstr鰉,L.; van der Veen,T.; Hallema,J.-P.; Mohell,N.; Unelius,L.; Johansson,R.; Wikstr鰉,H.V.; Grol,C.J.
参考来源:Bioorg Med Chem 1998,6(11),2111

SL-3111

Chemical Name: 4-Benzyl-1-(4-tert-butyl-3'-hydroxybenzhydryl)piperazine dihydrochloride
CAS No. 219505-08-5 (free base)
项目整合开发状态: Biological Testing
项目研究机构: University of Arizona (Originator)...
参考文献标题:De novo design,synthesis,and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor
文献作者:Liao,S.; Alfaro-Lopez,J.; Shenderovich,M.D.; Hosohata,K.; Lin,J.; Li,X.; Stropova,D.; Davis,P.; Jernigan,K.A.; Porreca,F.; Yamamura,H.I.; Hruby,V.J.
参考来源:J Med Chem 1998,41(24),4767