SL-3111
Chemical Name: 4-Benzyl-1-(4-tert-butyl-3'-hydroxybenzhydryl)piperazine dihydrochloride
CAS No. 219505-08-5 (free base)
项目整合开发状态: Biological Testing
项目研究机构: University of Arizona (Originator)
合成路线:Protection of 3-hydroxybenzaldehyde (I) with methoxymethyl chloride afforded the corresponding methoxymethyl ether (II).Subsequent addition of 4-tert-butylphenylmagnesium bromide (III) produced the diarylcarbinol (IV),which was converted to chloride (V) by means of CCl4 and PPh3.Condensation of (V) with 1-benzylpiperazine (VI) yielded the disubstituted piperazine (VII).The methoxymethyl ether of (VII) was finally deprotected with aqueous HCl to provide the title compound.
📌 参考资料/链接：
参考文献标题:De novo design,synthesis,and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor
文献作者:Liao,S.; Alfaro-Lopez,J.; Shenderovich,M.D.; Hosohata,K.; Lin,J.; Li,X.; Stropova,D.; Davis,P.; Jernigan,K.A.; Porreca,F.; Yamamura,H.I.; Hruby,V.J.
参考来源:J Med Chem 1998,41(24),4767