新产品编号:470363

Chemical Name: (?-(6S*,7R*)-8-Oxo-7-(2-phenylacetamido)-3-(trifluoromethylsulfonyloxy)-1,4-diazabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No. 219118-51-1
项目整合开发状态: Biological Testing
项目研究机构: Academia Sinica (Originator), National Tsing Hua University (Originator)
合成路线:The racemic cis-beta-lactam mesylate (I) was treated with NaN3 in DMF to give azide (II).Catalytic hydrogenation of (II) over Pd/C produced reduction to amine with concomitant cyclization to furnish the bicyclic compound (III).Further condensation of (III) with trifluoromethanesulfonyl chloride and pyridine provided a 3:1 mixture of triflates (IV) and (V).After chromatographic isolation of the required triflate (IV),deprotection of its benzyl ester by hydrogenolysis in the presence of PdCl2 yielded the title compound.