项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

新产品编号:163455

Chemical Name: 4-[4-(4-Fluorophenyl)-1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine
CAS No. 180869-35-6
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Origina...
参考文献标题:Certain 1,4,5-tri-substd.imidazole cpds.useful as cytokine
文献作者:Adams,J.L.; Gallagher,T.F.; Garigipati,R.S.; Boehm,J.C.; Sisko,J.; Peng,Z.-Q.; Lee,J.C.-L.(SmithKline Beecham plc)
参考来源:EP 0809499; JP 1998512555; US 5593992; WO 9621452

RS-113456

Chemical Name: 4-[4-(4-Chlorophenoxy)phenylsulfonyl]tetrahydro-2H-pyran-4-acetohydroxamic acid
CAS No. 193022-21-8
项目整合开发状态: Preclinical
项目研究机构: Roche Bioscience (Originator)
合成路线:The cond...
参考文献标题:Matrix metalloprotease inhibitors
文献作者:Campbell,J.A.; Bender,S.L.; Broka,C.A.; Sarma,K.; Fisher,L.E.; Castelhano,A.L.; Hendricks,R.T.(Agouron Pharmaceuticals,Inc.; F.Hoffmann-La Roche AG)
参考来源:EP 0780386

PDP, CC-1069

Chemical Name: 3-(3,4-Dimethoxyphenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propionamide; 3-(3,4-Dimethoxyphenyl)-3-(phthalimido)propionamide
CAS No. 167887-03-8
项目整合开发状态: Preclinical
项目...
参考文献标题:Ring closure of N-phthaloylglutamines
文献作者:Muller,G.W.(Celgene Corp.)
参考来源:EP 1004572; EP 1004580; US 5463063; WO 9501348

Caproctamine

Chemical Name: N,N'-Octamethylenebis[6-[N-(2-methoxybenzyl-N-methylamino]-N-methylhexanamide]
CAS No. 216174-98-0
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Bologna (Origin...
参考文献标题:Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease
文献作者:Melchiorre,C.; Andrisano,V.; Bolognesi,M.L.; Budriesi,R.; Cavalli,A.; Cavrini,V.; Rosini,M.; Turmiatti,V.; Recanatini,M.
参考来源:J Med Chem 1998,41(22),4186

RWJ-68354

Chemical Name: 6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridinyl)-1H-pyrrolo[2,3-b]pyridine
CAS No. 215306-39-1
项目整合开发状态: Preclinical
项目研究机构: R.W. Johnson (Originator)
合成路线:Condensation ...
参考文献标题:6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)
文献作者:Henry,J.R.; Rupert,K.C.; Dodd,J.H.; Turchi,I.J.; Wadsworth,S.A.; Cavender,D.E.; Fahmy,B.; Olini,G.C.; Davis,J.E.; Pellegrino-Gensey,J.L.; Schafer,P.H.; Siekierka,J.J.
参考来源:J Med Chem 1998,41(22),4196

LG-120744

Chemical Name: (Z)-5-(3-Fluorobenzylidene)-2,2,4-trimethyl-2,5-dihydro-1H-[1]benzopyrano[3,4-f]quinoline
CAS No. 179895-59-1
项目整合开发状态: Preclinical
项目研究机构: Ligand (Originator)
合成路线:The Skra...
参考文献标题:Steroid receptor modulator cpds.and methods
文献作者:Jones,T.K.; Goldman,M.E.; Pooley,C.L.F.; Winn,D.T.; Edwards,J.E.; West,S.J.; Tegley,C.M.; Zhi,L.; Hamann,L.G.; Farmer,L.J.; Davis,R.J.(Ligand Pharmaceuticals,Inc.)
参考来源:EP 0800519; JP 1998510840; US 5688808; US 5688810; US 5693646; US 5693647; US 5696127; US 5696130; US 5696133; WO 9619458

FR-195249(hydrochloride), FR-186485

Chemical Name: N-Cycloheptyl-N-[4-(4-fluorophenoxy)benzyl]-N'-(2,4,6-trimethylpyridin-3-yl)urea
CAS No. 179054-00-3, 179055-12-0 (monoHCl)
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)

新产品编号:313745

Chemical Name: 1-(Cyclohexylmethyl)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-3-methylindole-6-carboxamide
CAS No. 201285-35-0
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
合成路线:Met...
参考文献标题:Orally active indole N-oxide PDE4 inhibitors
文献作者:Hulme,C.; Mathew,R.; Moriarty,K.; Miller,B.; Ramanjulu,M.; Cox,P.; Souness,J.; Page,K.M.; Uhl,J.; Travis,J.; Labaudiniere,R.; Huang,F.; Djuric,S.W.
参考来源:Bioorg Med Chem Lett 1998,8(21),3053

新产品编号:479855

Chemical Name: N-(3-Phenyl-1,2,4-oxadiazol-5-ylmethyl)phthalimide ; 2-(3-Phenyl-1,2,4-oxadiazol-5-ylmethyl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS No. 219611-74-2
项目整合开发状态: Preclinical
项目研究机构...
参考文献标题:New phthalimide derivatives with potent analgesic activity: II
文献作者:Antunes,R.; Batista,H.; Srivastava,R.M.; Thomas,G.; Araujo,C.C.
参考来源:Bioorg Med Chem Lett 1998,8(21),3071

AT-5015

Chemical Name: 8(S)-(Chloromethyl)-4-[3(R)-(hydroxymethyl)morpholin-4-yl]-6-[5-(7-methoxybenzofuran-2-ylcarboxamido)-1H-indol-2-ylcarbonyl]-2-(trifluoromethyl)-3,6,7,8-tetrahydrobenzo[1,2,-b:4,3-b']di...
参考文献标题:Pyrroloindole derivs.and intermediates in producing the same
文献作者:Shimazawa,R.; Terashima,S.; Fukuda,Y.; Oomori,Y.(Kyorin Pharmaceutical Co.,Ltd.; Sagami Chemical Research Center)
参考来源:EP 0972775; JP 1998265473; US 6080859; WO 9832757