RWJ-68354
Chemical Name: 6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridinyl)-1H-pyrrolo[2,3-b]pyridine
CAS No. 215306-39-1
项目整合开发状态: Preclinical
项目研究机构: R.W. Johnson (Originator)
合成路线:Condensation of 4-(tert-butyldimethylsilyloxymethyl)pyridine (I) with ethyl 4-fluorobenzoate (II) using NaHMDS gave the silyloxyketone (III).Then,cyclization of (III) with 2,6-diamino-4-methoxypyridine (IV) in the presence of H2SO4 in refluxing dimethoxyethane provided the target pyrrolopyridine.
📌 参考资料/链接：
参考文献标题:6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)
文献作者:Henry,J.R.; Rupert,K.C.; Dodd,J.H.; Turchi,I.J.; Wadsworth,S.A.; Cavender,D.E.; Fahmy,B.; Olini,G.C.; Davis,J.E.; Pellegrino-Gensey,J.L.; Schafer,P.H.; Siekierka,J.J.
参考来源:J Med Chem 1998,41(22),4196