新产品编号:479855
Chemical Name: N-(3-Phenyl-1,2,4-oxadiazol-5-ylmethyl)phthalimide ; 2-(3-Phenyl-1,2,4-oxadiazol-5-ylmethyl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS No. 219611-74-2
项目整合开发状态: Preclinical
项目研究机构: Universidade Federal da Paraiba (Originator), Universidade Federal de Pernambuco (Originator)
合成路线:Reaction of glycine (II) with phthalic anhydride (I) in a microwave oven gave phthaloylglycine (III).Subsequent condensation with phenylamidoxime (IV) in the presence of DCC in dimethoxyethane afforded the O-acyl intermediate (V),which on heating cyclized to the title oxadiazole.
📌 参考资料/链接:
参考文献标题:New phthalimide derivatives with potent analgesic activity: II
文献作者:Antunes,R.; Batista,H.; Srivastava,R.M.; Thomas,G.; Araujo,C.C.
参考来源:Bioorg Med Chem Lett 1998,8(21),3071