AT-5015

Chemical Name: 8(S)-(Chloromethyl)-4-[3(R)-(hydroxymethyl)morpholin-4-yl]-6-[5-(7-methoxybenzofuran-2-ylcarboxamido)-1H-indol-2-ylcarbonyl]-2-(trifluoromethyl)-3,6,7,8-tetrahydrobenzo[1,2,-b:4,3-b']dipyrrole-1-carboxylic acid methyl ester
CAS No. 211053-39-3, 211053-38-2 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Kyorin (Originator), Sagami (Originator)
合成路线:The known phenolic antibiotic (I) was treated with p-nitrophenyl chloroformate (II) in the presence of Et3N to give carbonate (III).Then,condensation of (III) with (R)-3-(hydroxymethyl)morpholine (IV) furnished the target carbamate.