新产品编号:462453
Chemical Name: 5-(Benzyloxycarbonylamino)pentanoic acid 3-oxo-2,3-dihydrobenzisothiazol-2-ylmethyl ester S,S-dioxide
CAS No. 218270-47-4
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The title compound was prepared by condensation of 2-(bromomethyl)-1,2-benzisothiazol-3(2H)-one S,S-dioxide (I) with N-(benzyloxycarbonyl)-5-aminopentanoic acid (II) in the presence of K2CO3.
📌 参考资料/链接：
参考文献标题:1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase
文献作者:Combrink,K.D.; G黮geze,H.B.; Meanwell,N.A.; Pearce,B.C.; Zulan,P.; Bisacchi,G.S.; Roberts,D.G.; Stanley,P.; Seiler,S.M.
参考来源:J Med Chem 1998,41(24),4854