新产品编号:468781
Chemical Name: 2'-Deoxy-2'-(3-methoxybenzamido)-N6-(2-methylbenzyl)adenosine
CAS No. 218924-80-2
项目整合开发状态: Biological Testing
项目研究机构: Howard Hughes Medical Institute (Originator), University of Washington (Originator)
合成路线:The silyl-protected 2'-amino-2'-deoxyadenosine (I) was acylated with 3-methoxybenzoyl chloride (II) to give the corresponding amide (III).Alkylation of (III) at N1 with 2-methylbenzyl bromide (IV),with subsequent Dimroth rearrangement using isopropyl amine in MeOH provided the N6-(2-methylbenzyl)adenosine derivative (V).Finally,fluoride-promoted desilylation of (V) in MeOH furnished the title compound.
📌 参考资料/链接：
参考文献标题:Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design
文献作者:Aronov,A.M.; Verlinde,C.L.; Hol,W.G.; Gelb,M.H.
参考来源:J Med Chem 1998,41(24),4790