新产品编号:464035

Chemical Name: 1-(4-Bromophenyl)-2-methyl-4,9-dihydro-1H-imidazo[4,5-g]quinoxaline-4,9-dione
CAS No. 218271-09-1
项目整合开发状态: Biological Testing
项目研究机构: Ewha Womans University (Originator), Korea Inst. Sci. Technol. (Originator)
合成路线:Treatment of 6,7-dichloro-5,8-quinoxalinedione (I) with sodium azide in AcOH afforded azide (II),which was reduced to amine (III) using NaBH4.Acetylation of (III) with Ac2O and a catalytic amount of H2SO4 yielded amide (IV).Subsequent reaction of (IV) with 4-bromoaniline (V) produced the corresponding (4-bromophenyl)aminoquinoxaline (VI).Finally,conversion of (VI) into the target imidazole was performed by treatment with NaOH in refluxing EtOH.