项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Tosufloxacin tosilate, TN-3262a, T-3262a, T-3262, Tosuxacin, Ozex

甲苯磺酸妥苏沙星(T 3262) 甲苯磺酸妥舒沙星托氟沙星Chemical Name: (?-7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate monohydrate
CAS N...
参考文献标题:TOSUFLOXACIN TOSYLATE < Prop INNM >
文献作者:Soejima,R.; Shimada,K.
参考来源:Drugs Fut 1989,14(6),536

FTI-277

甲酮,二-4-异[口噁]唑基-(9CI)Chemical Name: N-[5-[2(R)-Amino-3-sulfanylpropylamino]biphenyl-2-ylcarbonyl]-L-methionine methyl ester
CAS No. 170006-73-2 (free base)
项目整合开发状态: Preclinical
项目研究机构: Univer...
参考文献标题:Inhibitors of prenyl transferases
文献作者:Sebti,S.; Hamilton,A.(University of Pittsburgh)
参考来源:JP 1998512266; WO 9621456

Metuclazepam, Brometazepam, Metaclazepam, KC-2547, KA-2547, Talis

甲酯 7-溴-5-(2-氯苯基)-2,3-二氢-2-(甲氧基甲基)-1-甲基-1H-苯并-1,4-二氮杂卓单盐酸盐 Chemical Name: 7-Bromo-5-(2-chlorophenyl)-2-(methoxymethyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepine
CAS No. 65517-27-3, 61802-93-5 (mono...
参考文献标题:Process for making benzodiazepine derivatives
文献作者:Milkowski,W.; Budden,R.; Funke,S.; Hueschens,R.; Liepmann,H.; Stuehmer,W.; Zeugner,H.(Kali-Chemie AG)
参考来源:US 4098786

BCN-326862, WIN-71425, SW-71425, SR-271425

甲酰胺,N-[[1-[[2-(二乙胺基)乙基]-7-甲氧基-9-氧代-9H-噻氧酜-4-基]甲基]-Chemical Name: N-[1-[2-(Diethylamino)ethylamino]-7-methoxy-9-oxo-9H-thioxanthen-4-ylmethyl]formamide; 1-[2-(Diethylamino)ethylamino]-4-(formamidomethy...
参考文献标题:Thioxanthenone antitumor agents
文献作者:Miller,T.C.; Collins,J.C.; Wentland,M.P.; Perni,R.B.; Corbett,T.H.; Mattes,K.C.(Sanofi-Synthabo)
参考来源:EP 0518414; EP 0619315; EP 0882723; JP 1993178853; JP 1994340655; US 5346917

R-113281

甲醇,[(2R)-2-(3,4-二氯苯基)-2-[2-[(2S)-2-氧化螺[苯并[c]噻吩-1(3H),4'-哌啶]-1'-酰基]-4-吗啡酰基](3,4,5-三甲氧基苯基),盐酸盐(1:1) ((2R)-2-(3,4-二氯苯基)-2-(2-(2-(2-氧螺素(1H-2-苯并噻吩-3,4'-哌啶)-1'-基)乙基)吗啡素-4-基)-(3,4,5-三甲氧基苯基)甲基 Chemical Name: ...
参考文献标题:Azaheterocyclic cpds.having tachykinin receptor antagonist activity; NK1 and NK2
文献作者:Kurata,H.; Ito,K.; Nakajima,K.; Yamaguchi,T.; Ishibashi,K.; Fukuzawa,T.; Nishi,T.(Sankyo Co.,Ltd.)
参考来源:EP 0776893; JP 1998152478; JP 1998182649; JP 1998182650

TEI-4120

甲醇,[1-(2-乙氧基-1-甲基乙基)-2-甲基-1H-吲哚-3-基]苯基-Chemical Name: [1-(2-Ethoxy-1-methylethyl)-2-methyl-1H-indol-3-yl]phenylmethanone; 3-Benzoyl-N-(1-ethoxy-2-propyl)-2-methylindole; 3-Benzoyl-N-beta-ethoxyisoprop...
参考文献标题:Acylated indole derivatives,processes for their preparation and pharmaceutical compositions and drugs comprising them
文献作者:Oba,T.; et al.(Teijin Ltd.)
参考来源:EP 0022634; JP 8107762; JP 81108765; JP 8139068; JP 8151452; JP 8163960

Penbutolol sulfate, Hoe-893d, Hoe-39893d, Levatol, Betapressin

甲醇中喷布特罗溶液标准物质喷布洛尔 Chemical Name: (S)-1-(2-Cyclopentylphenoxy)-3-(1,1-dimethylethylamino)-2-propanol sulfate (2:1)
CAS No. 38363-32-5, 38363-40-5 (free base)
项目整合开发状态: Launched-1981
项目研究机构: A...
参考文献标题:
文献作者:Ruschig,H.; et al.
参考来源:ZA 6807915

Metergoline, FI-6337, Liserdol

甲麦角林Chemical Name: (+)-(1,6-Dimethylergoline-8beta-ylmethyl)carbamic acid benzyl ester
CAS No. 17692-51-2
项目整合开发状态: Launched-1987
项目研究机构: Pfizer (Originator), Wyeth Pharmaceuticals (Not Deter...
参考文献标题:6-Methyl- and 1,6-dimethyl-8beta-carbobenzyloxy-aminomethyl-10alpha-ergoline as inhibitors of prolactin secretion
文献作者:di Salle,E.; Praga,C.; Castegnaro,E.
参考来源:US 4151283

AF-2364

男用口服避孕药Chemical Name: 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carbohydrazide
CAS No. 252025-52-8
项目整合开发状态: Preclinical
项目研究机构: Angelini (Originator)
合成路线:The described compound can be obtaine...
参考文献标题:3-Substd.1-benzyl-1H-indazole derivs.as antifertility agents
文献作者:Cheng,C.Y.; Silvestrini,B.(Angelini Pharmaceuticals Inc.)
参考来源:US 6001865

Uvaricin-(+), (+)-Uvaricin

番荔枝内酯Chemical Name: 3-[13(R)-[(2R,2'R,5R,5'R)-5'-[1(S)-(Acetyloxy)undecyl]octahydro[2,2'-bifuran]-5-yl]-13-hydroxytridecyl]-5(S)-methyl-2(5H)-furanone
CAS No. 82064-83-3
项目整合开发状态: Preclinical 参考文献标题:Total synthesis of uvaricin
文献作者:Yazbak,A.; Sinha,S.C.; Keinan,E.
参考来源:J Org Chem 1998,63(17),5863