AF-2364
男用口服避孕药Chemical Name: 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carbohydrazide
CAS No. 252025-52-8
项目整合开发状态: Preclinical
项目研究机构: Angelini (Originator)
合成路线:The described compound can be obtained by treatment of carboxaldehyde (I) with potassium acetate (II) and acetic anhydride.
合成路线:The title hydrazide is prepared by treatment of methyl 1-(2,4-dichlorobenzyl)indazole-3-carboxylate (I) with hydrazine hydrate in boiling acetic acid.
📌 参考资料/链接：
参考文献标题:3-Substd.1-benzyl-1H-indazole derivs.as antifertility agents
文献作者:Cheng,C.Y.; Silvestrini,B.(Angelini Pharmaceuticals Inc.)
参考来源:US 6001865
📄 详细内容
合成路线:The title hydrazide is prepared by treatment of methyl 1-(2,4-dichlorobenzyl)indazole-3-carboxylate (I) with hydrazine hydrate in boiling acetic acid.
参考文献标题:Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis
文献作者:Cheng,C.Y.; Silvestrini,B.; Grima,J.; Mo,M.Y.; Zhu,L.J.; Johansson,E.; Saso,L.; Leone,M.G.; Palmery,M.; Mruk,D.
参考来源:Biol Reprod 2001,65(2),449
产品链接: CAS No. 252025-52-8››