项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Resveratrol

白藜芦醇Chemical Name: 3,4',5-Trihydroxy-trans-stilbene
CAS No. 501-36-0
项目整合开发状态: Preclinical
项目研究机构: National Cancer Institute (Not Determined)
合成路线:The reaction of 3,5-dihydroxybenzoic acid...
参考文献标题:Synthesis of resveratrol
文献作者:Meredith,E.; Andrus,M.(Brigham Young University)
参考来源:WO 0160774

SNS-595, SPC-595, AG-7352

白血病孤儿药 (3S-反式)-1,4-二氢-7-[3-甲氧基-4-(甲基氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸单盐酸盐 Chemical Name: (+)-7-[3(S)-Methoxy-4(S)-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(2-thiazolyl)-1,4-dihydro-1,8-naphthyridine...
参考文献标题:Novel cpd.,process for producing the same,and antitumor agent
文献作者:Tomita,K.; Chiba,K.; Kashimoto,S.; Shibamori,K.; Tsuzuki,Y.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:EP 0787726; US 5817669; WO 9534559

Z-203, T-0632

盐(S)-1-(2-氟苯基)-3-(3-异喹啉基碳杂草酰氨基)-6-甲氧基-2-羰基-1H-吲哚-3-丙酸钠Chemical Name: (S)-1-(2-Fluorophenyl)-3-(3-isoquinolinylcarboxamido)-6-methoxy-2-oxo-1H-indole-3-propionic acid sodium salt
CAS No. 169042-78-8...
参考文献标题:2-Oxoindoline deriv.
文献作者:Yamada,K.; Hikota,M.; Shikano,T.; Nagasaki,M.(Tanabe Seiyaku Co.,Ltd.)
参考来源:EP 0731091; US 5807883; WO 9514668

Z-335

盐2-[2-(4-氯苯磺酰氨基甲基)铟烷-5-基]乙酸钠Chemical Name: 2-[2-(4-Chlorophenylsulfonamidomethyl)indan-5-yl]acetic acid sodium salt
CAS No. 146731-14-8, 146737-36-2 (free acid)
项目整合开发状态: Phase II
项目研究机构: Zer...
参考文献标题:Synthesis and thromboxane A2 antagonistic activity of indane derivatives
文献作者:Shinozaki,K.; Sato,H.; Iwakuma,T.; Sato,R.; Kurimoto,T.; Yoshida,K.
参考来源:Bioorg Med Chem Lett 1999,9(3),401

[125I]-SB-258585

盐酸4-碘-N-[4-甲氧基-3-(4-甲基-1-哌嗪)苯基]苯磺酰胺Chemical Name: 4-[125I]Iodo-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide
CAS No. 209480-63-7 (non-labeled)
项目整合开发状态: Biological Testing
...
参考文献标题:Sulphonamide derivs.,process for their preparation,and their use as medicaments
文献作者:King,F.D.; Bromidge,S.M.; Wyman,P.A.(SmithKline Beecham plc)
参考来源:WO 9827081

HEAT, BE-2254

盐酸HEAT(BE2254) 2-[[2-(4-羟基苯基)乙胺基]甲基]-3,4-二氢-2H-萘-1-酮 Chemical Name: 3,4-Dihydro-2-[[(p-hydroxyphenethyl)amino]methyl]-1(2H)-naphthalenone hydrochloride; 3,4-Dihydro-2-[[[2-(4-hydroxyphenyl)ethyl]amino...
参考文献标题:BE-2254
文献作者:Hofferber,E.
参考来源:Drugs Fut 1982,7(4),231

Vancomycin hydrochloride, Vancocin Pulvules, Vancomycin Enterocaps, Vancomycin CP, Vancocine, Vanconcina A.P., Vancocin

盐酸万古霉素万古霉素 Chemical Name: (3S,6R,7R,22R,23S,26S,36R,38aR)-3-(Carbamoylmethyl)-10,19-dichloro-44-[2-O-[3-C-amino-3-C-methyl-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl]-beta-D-glucopyranosyloxy]-7,22,28...
参考文献标题:Synthesis of vancomycin from the aglycon
文献作者:Thompson,C.; et al.
参考来源:J Am Chem Soc 1999,121(6),1237

Propacetamol hydrochloride, UP-34101, Pro-efferalgan, Pro-Dafalgan

盐酸丙帕他莫丙帕他莫 Chemical Name: N,N-Diethylglycine 4-(acetylamino)phenyl ester hydrochloride
CAS No. 66532-86-3, 66532-85-2 (free base)
项目整合开发状态: Launched-1985
项目研究机构: Bristol-Myers Squibb (Origin...
参考文献标题:P-Acetamidophenyl diethylaminoacetate
文献作者:Cognacq,J.-C.(Hexachimie SA)
参考来源:BE 854376; US 4127671

Masnidipine hydrochloride, Lercanidipine hydrochloride, TJN-324, Rec-15/2375, Lercan, Cardiovasc, Lerzam, Zanidip, Lerdip, Lercadip, Zanedip

盐酸乐卡地平乐卡地平 Chemical Name: (?-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 2-[N-(3,3-diphenylpropyl)-N-methylamino]-1,1-dimethylethyl methyl diester hydrochloride
CAS No...
参考文献标题:N-(3,3-diphenylpropyl)aminoethylesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid,compositions and use
文献作者:Nardi,D.; Leonardi,A.; Graziani,G.; Bianchi,G.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:EP 0153016; JP 60199874; US 4772621; US 4968832

Eperisone hydrochloride, E-2000(tape), EMPP, Myonal

盐酸乙哌立松乙哌立松 Chemical Name: 4'-Ethyl-2-methyl-3-piperidinopropiophenone hydrochloride; 4-Ethyl-alpha-methyl-beta-piperidinopropiophenone hydrochloride; 1-(4-Ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-pr...
参考文献标题:Propiophenone derivatives in the treatment of pathological muscular conditions
文献作者:Morita,E.; Kanai,T.(Eisai Co.,Ltd.)
参考来源:US 3995047; US 4181803