项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Difloxacin hydrochloride, A-56619, ABBOTT-56619

盐酸二氟沙星双氟沙星 Chemical Name: 1-(4-Fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)quinoline-3-carboxylic acid hydrochloride
CAS No. 91296-86-5, 98106-17-3 (free base)
项目整合开发状态: ...
参考文献标题:Abbott-56619
文献作者:Granneman,G.R.; Chu,D.T.W.; Fernandes,P.B.
参考来源:Drugs Fut 1985,10(7),543

Bifemelane Hydrochloride, BFM-2703, E-0687, MCI-2016, Celeport, Alnert

盐酸二苯美伦二苯美伦 Chemical Name: N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine hydrochloride; 2-(4-Methylaminobutoxy)diphenylmethane hydrochloride
CAS No. 62232-46-6, 90293-01-9 (free base)
项目整合开...
参考文献标题:Process for preparation of 2-(omega-aminoalkyloxy)diphenylmethanes
文献作者:Kikumoto,R.; et al.(Mitsubishi Chemical Corp.)
参考来源:JP 52033658

Talipexole dihydrochloride, BHT-920, B-HT-920, Domin

盐酸他利克索他利克索 Chemical Name: 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine dihydrochloride
CAS No. 36085-73-1, 101626-70-4 (free base)
项目整合开发状态: Launched-1996
项目研究机构: Boehringer ...
参考文献标题:2-Amino-4,5,7,8-tetrahydro-6H-thiazolo or oxazolo[5,4-d]azepines and salts
文献作者:Griss,G.; Kleemann,M.; Grell,W.; Ballhause,H.(Boehringer Ingelheim GmbH)
参考来源:DE 2127267; ES 396454; FR 2102192; GB 1321509; NL 7111176; US 3804849

Itopride hydrochloride, HSR-803, Itax, Ganaton

盐酸伊托必利伊托必利 Chemical Name: N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride
CAS No. 122892-31-3, 122898-67-3 (free base)
项目整合开发状态: Launched-1995
项目研究机构: Abbott (Orig...
参考文献标题:Amide cpds.,process for preparing the same,and compsn.for activating gastric motor function containing the same
文献作者:Itoh,Y.; Kato,H.; Koshinaka,E.; Ogawa,N.; Nishino,H.; Sakaguchi,J.(Hokuriku Seiyaku Co.,Ltd.)
参考来源:AU 8821862; EP 0306827; JP 1989066153; JP 1989079144; JP 1989085960; JP 1989093568; US 4983633

Vapiprost hydrochloride, SN-309, GR-32191B

盐酸伐普前列素伐哌前列素 Chemical Name: [1R-[1alpha(Z),2beta,3beta,5alpha]]-(+)-7-[5-[(1,1'-Biphenyl)-4-ylmethoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride; (Z)-(1R,2R,3S,5S)-7-[5-(...
参考文献标题:VAPIPROST HYDROCHLORIDE < Rec INNM; BAN >
文献作者:Lumley,P.; Finch,H.; Collington,E.W.C.; Humphrey,P.P.A.
参考来源:Drugs Fut 1990,15(11),1087

Zorubicin hydrochloride, NSC-164011, RP-22050, Rubidazone

盐酸佐柔比星佐柔比星 Chemical Name: 2-Benzoylhydrazone of daunorubicin hydrochloride; (2S-cis)-Benzoic acid [1-[4-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydro...
参考文献标题:Zorubicin
文献作者:Castar,J.; Woodman,R.J.
参考来源:Drugs Fut 1979,4(1),61

Eltoprazine Hydrochloride, DU-28853

盐酸依托拉嗪依托拉嗪 Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride
CAS No. 98206-09-8, 98224-03-4 (free base)
项目整合开发状态: Phase II
项目研究机构: Duphar (Originator), Solvay (Orig...
参考文献标题:ELTOPRAZINE HYDROCHLORIDE < Prop INN >
文献作者:Hartog,J.; Olivier,B.
参考来源:Drugs Fut 1988,13(3),222

Efonidipine hydrochloride ethanol, NZ-105, Landel

盐酸依福地平依福地平 Chemical Name: (?-5-(5,5-Dimethyl-1,3,2-dioxaphosphorinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 2-(N-benzyl-N-phenylamino)ethyl ester P-oxide hydrochlo...
参考文献标题:Synthesis of 1,4-dihydropyridine-5-phosphonates and their calcium antagonistic and antihypertensive activities: Novel calcium-antagonist NZ-105 and its crystal structure
文献作者:Sakoda,R.; Kamikawaji,Y.; Seto,K.
参考来源:Chem Pharm Bull 1992,40(9),2362

Irinotecan hydrochloride, U-101440E(hydrate), NSC-616348, DQ-2805, CPT-11, Camptosar, Topotecin, Campto

盐酸依立替康伊立替康 Chemical Name: [1,4'-Bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride; (+)...
参考文献标题:New camptothecin derivs.and process for preparing same
文献作者:Miyasaka,T.; Mutai,M.; Nokata,K.; Sawada,S.; Sugino,E.(Yakult Honsha Co.,Ltd.)
参考来源:EP 0137145; JP 1985019790

Betaxolol hydrochloride, MCI-144, SL-75212, Betoptima, Kerlong, Betoptic, Kerlone

盐酸倍他洛尔倍他洛尔 Chemical Name: (?-1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol hydrochloride
CAS No. 63659-19-8, 63659-18-7 (free base)
项目整合开发状态: Launched-1983
项目研究机构:...
参考文献标题:Phenol ethers
文献作者:Manoury,P.M.J.; et al.(Sanofi-Synthabo )
参考来源:DE 2649605; FR 2330383; GB 1515978; JP 52085146; US 4252984