Eltoprazine Hydrochloride, DU-28853
盐酸依托拉嗪 依托拉嗪 Chemical Name: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride
CAS No. 98206-09-8, 98224-03-4 (free base)
项目整合开发状态: Phase II
项目研究机构: Duphar (Originator), Solvay (Originator)
合成路线:Eltoprazine can be obtained in a 3-step procedure starting from 5-nitrobenzodioxane (I):Catalytic hydrogenation of benzodioxane (I) results in the aniline hydrochloride (II) in high yieId.From the crude product obtained after treatment of (II) with bischloroethylamine dihydrochloride and subsequent crystallization from ethanol,pure eltoprazine hydrochloride is isolated.
📌 参考资料/链接：
参考文献标题:ELTOPRAZINE HYDROCHLORIDE < Prop INN >
文献作者:Hartog,J.; Olivier,B.
参考来源:Drugs Fut 1988,13(3),222
📄 详细内容
合成路线:Eltoprazine can be obtained in a 3-step procedure starting from 5-nitrobenzodioxane (I):Catalytic hydrogenation of benzodioxane (I) results in the aniline hydrochloride (II) in high yieId.From the crude product obtained after treatment of (II) with bischloroethylamine dihydrochloride and subsequent crystallization from ethanol,pure eltoprazine hydrochloride is isolated.
参考文献标题:Method of preparing 5-amino-1,4-benzodioxane.
文献作者:Martikus,R.S.; Udrenajte,E.B.; Daukshas,V.K.; Rimkunajte,L.V.(Viln G Univ Im V Kapuskasa)
参考来源:SU 456521
产品链接: CAS No. 98206-09-8›› 产品链接: CAS No.98224-03-4››