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Bifemelane Hydrochloride, BFM-2703, E-0687, MCI-2016, Celeport, Alnert

盐酸二苯美伦 二苯美伦 Chemical Name: N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine hydrochloride; 2-(4-Methylaminobutoxy)diphenylmethane hydrochloride
CAS No. 62232-46-6, 90293-01-9 (free base)
项目整合开发状态: Withdrawn-1999
项目研究机构: Eisai (Originator), Mitsubishi Chemical (Originator), Fujisawa (Licensee)
合成路线:The reaction of 2-hydroxydiphenylmethane (I) with 1,4-dibromobutane (II) in a basic medium affords 2-(4-bromobutoxy)diphenylmethane (III),which is then condensed with methylamine in water - ethanol at room temperature.
📌 参考资料/链接:
参考文献标题:Process for preparation of 2-(omega-aminoalkyloxy)diphenylmethanes
文献作者:Kikumoto,R.; et al.(Mitsubishi Chemical Corp.)
参考来源:JP 52033658

📄 详细内容


合成路线:The reaction of 2-hydroxydiphenylmethane (I) with 1,4-dibromobutane (II) in a basic medium affords 2-(4-bromobutoxy)diphenylmethane (III),which is then condensed with methylamine in water - ethanol at room temperature.

参考文献标题:MCI-2016
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1980,5(12),611


合成路线:The reaction of 2-hydroxydiphenylmethane (I) with 1,4-dibromobutane (II) in a basic medium affords 2-(4-bromobutoxy)diphenylmethane (III),which is then condensed with methylamine in water - ethanol at room temperature.

参考文献标题:2-Substituted-1-(omega-aminoalkoxy)benzenes
文献作者:Kikumoto,R.; et al.
参考来源:DE 2627227; FR 2315913; NL 7606668


合成路线:The reaction of 2-hydroxydiphenylmethane (I) with 1,4-dibromobutane (II) in a basic medium affords 2-(4-bromobutoxy)diphenylmethane (III),which is then condensed with methylamine in water - ethanol at room temperature.
参考文献标题:Pharmaceutically active 2-omega-aminoalkoxydiphenylmethanes
文献作者:Kikumoto,R.; et al.
参考来源:US 4091114


产品链接: CAS No. 62232-46-6››

产品链接: CAS No.90293-01-9››