Talipexole dihydrochloride, BHT-920, B-HT-920, Domin
盐酸他利克索 他利克索 Chemical Name: 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine dihydrochloride
CAS No. 36085-73-1, 101626-70-4 (free base)
项目整合开发状态: Launched-1996
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The bromination of 1-allylhexahydro-4H-azepin-4-one (I) with Br2 in acetic acid gives 1-allyl-5-bromohexahydro-4H-azepin-4-one (II),which is cyclized with thiourea (III) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:2-Amino-4,5,7,8-tetrahydro-6H-thiazolo or oxazolo[5,4-d]azepines and salts
文献作者:Griss,G.; Kleemann,M.; Grell,W.; Ballhause,H.(Boehringer Ingelheim GmbH)
参考来源:DE 2127267; ES 396454; FR 2102192; GB 1321509; NL 7111176; US 3804849
📄 详细内容
合成路线:The bromination of 1-allylhexahydro-4H-azepin-4-one (I) with Br2 in acetic acid gives 1-allyl-5-bromohexahydro-4H-azepin-4-one (II),which is cyclized with thiourea (III) in refluxing ethanol.
参考文献标题:B-HT-920
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.; Thorpe,P.J.
参考来源:Drugs Fut 1980,5(10),481
产品链接: CAS No. 36085-73-1›› 产品链接: CAS No.101626-70-4››