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项目整合精选>>>Tosufloxacin tosilate, TN-3262a, T-3262a, T-3262, Tosuxacin, Ozex
Tosufloxacin tosilate, TN-3262a, T-3262a, T-3262, Tosuxacin, Ozex
甲苯磺酸妥苏沙星(T 3262) 甲苯磺酸妥舒沙星 托氟沙星Chemical Name: (?-7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate monohydrate
CAS No. 115964-29-9, 107097-79-0 (free base), 108138-46-1 (free base, anhydrous)
项目整合开发状态: Launched-1990
项目研究机构: Toyama (Originator), Abbott (Licensee), Dong-A (Licensee), Nidek (Licensee), Otsuka (Comarketer)
合成路线:Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (I) is reacted with 3-aminopyrrolidine dihydrochloride (II),and then the resulting mixture is reacted with potassium hydroxide and p-toluenesulfonic acid monohydrate in order to obtain (rac)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate.
📌 参考资料/链接：
参考文献标题:TOSUFLOXACIN TOSYLATE < Prop INNM >
文献作者:Soejima,R.; Shimada,K.
参考来源:Drugs Fut 1989,14(6),536
📄 详细内容
合成路线:Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (I) is reacted with 3-aminopyrrolidine dihydrochloride (II),and then the resulting mixture is reacted with potassium hydroxide and p-toluenesulfonic acid monohydrate in order to obtain (rac)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate.
参考文献标题:Pyridonecarboxylic acids as antibacterial agents IV
文献作者:Narita,H.; Konishi,Y.; Nitta,J.; Nagaki,H.; Kobayashi,Y.; Watanabe,Y.; Minami,S.; Saikawa,I.
参考来源:Yakugaku Zasshi 1986,106795
合成路线:Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (I) is reacted with 3-aminopyrrolidine dihydrochloride (II),and then the resulting mixture is reacted with potassium hydroxide and p-toluenesulfonic acid monohydrate in order to obtain (rac)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate.
参考文献标题:Chemical structure and physicochemical properties of (rac)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluensulfonate hydrate (T-3262)
文献作者:Kokei,T.; et al.
参考来源:Iyakuhin Kenkyu 1988,19682