项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Gastrophenzine, DZO-200, AN5

氨基甲酸,[4-(4-氯苯基)-1,2,3,4-四氢-2-甲基-8-异喹啉基]-,乙酯,一盐酸盐(9CI)Chemical Name: 4-(4-Chlorophenyl)-8-(ethoxycarbonylamino)-2-methyl-1,2,3,4-tetrahydroisoquinoline monohydrochloride; [4-(4-Chlorophenyl)-2-methyl-1...
参考文献标题:Gastrophenzine
文献作者:Ivanova,N.; Angelova,J.; Mondeshka,D.; Ivanov,C.
参考来源:Drugs Fut 1992,17(2),104

Pimagedine, Aminoguanidine, YM-585, MDL-201228, GER-11(HCl)

氨基胍盐酸盐氨基胍盐酸盐 Chemical Name: Aminoguanidine; Guanylhydrazine
CAS No. 79-17-4, 1937-19-5 (monoHCl)
项目整合开发状态: Phase III
项目研究机构: Alteon (Originator), Yamanouchi (Licensee)
合成路线:The study of t...
参考文献标题:Synthesis of 14C-labelled aminoguanidine
文献作者:Lo,T.W.C.; Thornalley,P.J.
参考来源:J Label Compd Radiopharm 1994,34(2),179-83

Fosamprenavir sodium, GW-433908A, 908, VX-175(free acid)

氨基酸,[(1S,2R)-3-[[(4-氨基苯基)磺酰](2-甲基丙基)氨基]-1-(苯甲基)-2-(磷酸氧基)丙基]-,C-[(3S)-四氢-3-呋喃酰]酯,二钠盐(9CI) 福沙那韦 Chemical Name: N-[3-[N-(4-Aminophenylsulfonyl)-N-isobutylamino]-1(S)-benzyl-2(R)-(phosphonooxy)propyl]carb...
参考文献标题:Sulfonamide inhibitors of HIV-aspartyl protease
文献作者:Tung,R.D.; Murcko,M.A.; Bhisetti,G.R.(Vertex Pharmaceuticals Inc.)
参考来源:EP 0659181; EP 0885887; JP 1996501299; US 5585397; WO 9405639

Cymserine

氨基酸,N-[4-(1-甲基乙基)苯基]-,(3aS,8aR)-1,2,3,3a,8,8a-六氢-1,3a,8-三甲基吡咯罗[2,3-b]吲哚-5-伊酯Chemical Name: N-[4-(1-Isopropylphenyl)carbamic acid (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5...
参考文献标题:Substd.phenserines as specific inhibitors of acetylcholinesterase
文献作者:Brossi,A.; Brzostowska,M.; Rapoport,S.I.; Greig,N.; He,X.-S.(US Department of Health & Human Services)
参考来源:EP 0606366; JP 1995503703; US 5171750; WO 9306105

Vigabatrin, M071754, RMI-71890((+)-enantiomer), GVG, MDL-71754, RMI-71754, Sabrilex, Sabril

氨己烯酸Chemical Name: 4-Amino-5-hexenoic acid; gamma-VinylGABA
CAS No. 60643-86-9
项目整合开发状态: Launched-1989
项目研究机构: Ovation Pharmaceuticals (Proprietary), Aventis Pharma (Originator), Novartis (Li...
参考文献标题:RMI-71,754
文献作者:Blancafort,P.; Paton,D.M.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1981,6(6),363

Aztreonam, Corus-1020, SQ-26776, Primbactam, Azactam

氨曲南Chemical Name: [2S-[2alpha,3beta(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid inner salt
CAS No. 78110-38-0<...
参考文献标题:beta-Lactam antibiotics containing sulphonic groups
文献作者:Sykes,R.B.; Parker,W.L.; Cimarusti,C.M.; Koster,W.H.; Slusarchyk,W.A.; Fritz,A.W.; Floyd,D.M.(Bristol-Myers Squibb Co.)
参考来源:BE 0887428; DE 3104145; GB 2071650; JP 56125362

Amlexanox, Amoxanox, CHX-3673, AA-673, OraDisc A, Aptheal, Apthera, OraRinse, Aphthasol, Elics, Solfa

氨来呫诺Chemical Name: 2-Amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; 2-Amino-7-isopropyl-1-azaxanthone-3-carboxylic acid
CAS No. 68302-57-8
项目整合开发状态: Launched-1987 参考文献标题:1-Azaxanthone-3-carboxylic acid
文献作者:Nohara,A.; Sugihara,H.; Ukawa,K.(Takeda Chemical Industries,Ltd.)
参考来源:BE 0864647; DE 2809720; FR 2383185; GB 1597024; GB 1597025; JP 78111096; JP 78111097; JP 7988298; US 4143042; US 4255576; US 4299963

Amifloxacin, Win-493753(mesylate), Win-49375

氨氟沙星 6-氟-1-(甲基氨基)-7-(4-甲基哌哌嗪-1-基)-4-氧喹啉-1,4-二氢喹啉-3-羧酸甲烷磺酸盐(1:1) Chemical Name: 6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
CAS No. 86393-37-5, 8...
参考文献标题:New quinolone compounds and preparation thereof
文献作者:Wentland,M.P.; Bailey,D.M.(Sterling Winthrop Inc.)
参考来源:EP 0090424; JP 8401468

Amlodipine, UK-4834011, Norvasc(as besylate)

氨氯地平Chemical Name: (?-2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
CAS No. 88150-42-9
项目整合开发状态: Launched-1990
项目研究机构: Pfizer (Ori...
参考文献标题:2-(Secondary aminoalkoxymethyl)dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
文献作者:Campbell,S.F.; Cross,P.E.; Stubbs,J.K.(Pfizer Inc.)
参考来源:DD 218887; EP 0089167; JP 58167569; US 4572909

FR-900482

氨甲酸(1aS,8R,9aS)-5-甲酰基-7,9-二羟基-3,9-环氧-2,3,8,9,9a,9b-六氢-1H-吖丙因并[2,3-c][1]苯并吖辛因-8-基甲基酯Chemical Name: Carbamic acid (1aS,8R,9aS)-5-formyl-7,9-dihydroxy-3,9-epoxy-2,3,8,9,9a,9b-hexahydro-1H-azirino[2,3-c][...
参考文献标题:Total synthesis of natural (+)-FR900482.3.Completion of the synthesis
文献作者:Katoh,T.; et al.
参考来源:Tetrahedron Lett 1996,37(20),3479