项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Flosulide, CGP-28238, ZK-38997

氟舒胺Chemical Name: N-[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-inden-5-yl]methanesulfonamide; 6-(2,4-Difluorophenoxy)-5-methylsulfonylamino-1-indanone
CAS No. 80937-31-1
项目整合开发状态: Phase II
项目...
参考文献标题:Novel indanyl derivs.,their preparation and use
文献作者:Schr鰀er,E.; Rufer,C.; B鰐tcher,I.; Kapp,J.-F.(Schering AG)
参考来源:EP 0056956; US 4375479

Flubendazole

氟苯咪唑Chemical Name: 5-(4-Fluorobenzoyl)-1H-benzimidazol-2-ylcarbamic acid methyl ester
CAS No. 31430-15-6
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The Friedel Krafts reaction of fluoroben...
参考文献标题:Flubendazole.
文献作者:Castar,J.; Bogan,J.A.
参考来源:Drugs Fut 1978,3(10),739

Flesinoxan hydrochloride, DU-29373

氟菜西罗沙氟辛克生 Chemical Name: (+)-(S)-4-Fluoro-N-[2-[4-[2-(hydroxymethyl)-1,4-benzodioxan-5-yl]-1-piperazinyl]ethyl]benzamide monohydrochloride
CAS No. 98205-89-1, 98206-10-1 (free base)
项目整合开发状态: P...
参考文献标题:FLESINOXAN HYDROCHLORIDE < Rec INN >
文献作者:Hartog,J.; Wouters,W.
参考来源:Drugs Fut 1988,13(1),31

Flurocitabine, NSC-166641, AAFC

氟西他宾Chemical Name: (2R,3R,3aS,9aR)-7-Fluoro-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ol; 2,2'-Anhydro-1-(beta-D-arabinofuranosyl)-5-fluorocytosine
...
参考文献标题:
文献作者:Hoffer,M.
参考来源:AU 326837; DE 2342930; FR 2199468; GB 1389799; JP 7466696; NL 7312201; US 3899482; ZA 7305572

Flunoprost, ZK-95377

氟诺前列素Chemical Name: (Z)-7-[(1R,2R,3R,5R)-5-Fluoro-3-hydroxy-2-[(E)-(3R)-hydroxy-4-phenoxy-1-butenyl]cyclopentyl]-5-heptenoic acid; (9R,11R,15R)-9-Fluoro-11,15-dihydroxy-16-phenoxy-17,18,19,20-tetranor...
参考文献标题:9-Fluoroprostaglandin derivatives and use as medicinal agents
文献作者:Skuballa,W.; Rad點hel,B.; Schwarz,N.; Vorbr黦gen,H.; Elger,W.; Loge,O.; Town,M.-H.(Schering AG)
参考来源:DE 3126924; EP 0069696; JP 58008059; US 4454339; US 4789685

Flunoxaprofen, RV-12424, MK-830, Priaxim

氟诺洛芬Chemical Name: (S)-(?-2-(4-Fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
CAS No. 66934-18-7
项目整合开发状态: Launched-1986
项目研究机构: Ravizza (Originator)
合成路线:The acidic hydrolysis of 3-n...
参考文献标题:Flunoxaprofen
文献作者:Forgione,A.
参考来源:Drugs Fut 1986,11(3),187

Fludarabine, NSC-118218, 2-F-ara-A

氟达拉滨Chemical Name: 9-(beta-D-Arabinofuranosyl)-2-fluoro-9H-purin-6-amine; 9-(beta-D-Arabinofuranosyl)-2-fluoroadenine
CAS No. 21679-14-1
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compoun...
参考文献标题:F-ARA-A
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Hopkins,S.J.
参考来源:Drugs Fut 1982,7(8),561

Frakefamide, SPD-759, LEF-576, BCH-3963

氟雷法胺Chemical Name: L-Tyrosyl-D-alanyl-L-(4-fluoro)phenylalanyl-L-phenylalanylamide
CAS No. 188196-22-7, 244072-12-6 (hydrochloride)
项目整合开发状态: Phase II
项目研究机构: Shire BioChem (Originator)
合成...
参考文献标题:Novel opioid peptides
文献作者:Wang,W.(AstraZeneca plc)
参考来源:EP 0845003; JP 1999512086; US 6337319; WO 9707130

Falecalcitriol, Flocalcitriol, Hexafluorocalcitriol, DSC-103, Ro-23-4194, ST-630, Fulstan, Horner

氟骨三醇Chemical Name: (+)-1alpha,25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D3; (+)-(1alpha,3beta,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol; (+)-1alpha,25...
参考文献标题:26,26,26,27,27,27-Hexafluoro-1alpha,25-dihydroxycholecalciferol and process for preparing the same
文献作者:DeLuca,H.F.; Tanaka,Y.; Ikekawa,M.; Kobayashi,Y.(Wisconsin Alumni Research Foundation)
参考来源:JP 1994025280; US 4358406

Galanthamine hydrobromide, Galantamine hydrobromide, R-113675, GP-37267, Reminyl, Nivalin

氢溴酸加兰他敏加兰他敏 Chemical Name: (4aS,6R,8aS)-6-Hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzofuro[3a,3,2-e,f][2]benzazepine hydrobromide
CAS No. 1953-04-4, 357-70-0 (free base)
项目整合开...
参考文献标题:Dynamic diastereomeric salt resolution of narwedine and its transformation to (-)-galanthamine
文献作者:Chaplin,D.A.; et al.
参考来源:Tetrahedron Lett 1998,39(37),6777