合成路线:It can be prepared in two different ways both starting from 5-fluorocytidine (I):1) By reaction of (I) with partially hydrolyzed POCl3 in refluxing ethyl acetate (1),or DMF and acetonitrile (2).2) By reaction of (I) with o-acetoxybenzoyl chloride or 2-acetoxy-iso-butyryl chloride in refluxing acetonitrile to give the acetoxy compound (III),which is hydrolyzed with methanolic HCl (3,4).
参考文献标题:
文献作者:Hoffer,M.
参考来源:AU 33199; DE 2363536; GB 1407381; JP 7495998; NL 7316269; ZA 7308658
合成路线:It can be prepared in two different ways both starting from 5-fluorocytidine (I):1) By reaction of (I) with partially hydrolyzed POCl3 in refluxing ethyl acetate (1),or DMF and acetonitrile (2).2) By reaction of (I) with o-acetoxybenzoyl chloride or 2-acetoxy-iso-butyryl chloride in refluxing acetonitrile to give the acetoxy compound (III),which is hydrolyzed with methanolic HCl (3,4).
参考文献标题:Pyrimidine nucleosides.5.Syntheses of carcinostatic halogenocyclonucleosides
文献作者:Kanai,T.; Ichino,M.
参考来源:J Med Chem 1972,15(12),1218-1221
合成路线:It can be prepared in two different ways both starting from 5-fluorocytidine (I):1) By reaction of (I) with partially hydrolyzed POCl3 in refluxing ethyl acetate (1),or DMF and acetonitrile (2).2) By reaction of (I) with o-acetoxybenzoyl chloride or 2-acetoxy-iso-butyryl chloride in refluxing acetonitrile to give the acetoxy compound (III),which is hydrolyzed with methanolic HCl (3,4).
参考文献标题:Nucleosides XCIX.2-Acetoxybenzoyl chloride,a reagent for the direct synthesis of 2,2?anhydropyrimidine nucleosides
文献作者:Reichman,U.; et al.
参考来源:Synthesis 1976,8533-534
合成路线:It can be prepared in two different ways both starting from 5-fluorocytidine (I):1) By reaction of (I) with partially hydrolyzed POCl3 in refluxing ethyl acetate (1),or DMF and acetonitrile (2).2) By reaction of (I) with o-acetoxybenzoyl chloride or 2-acetoxy-iso-butyryl chloride in refluxing acetonitrile to give the acetoxy compound (III),which is hydrolyzed with methanolic HCl (3,4).
参考文献标题:Flurocitabine
文献作者:Castar,J.; Woodman,R.J.
参考来源:Drugs Fut 1978,3(9),647
产品链接: CAS No. 37717-21-8››