项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Flordipine, RHC-2906

氟地平Chemical Name: 2,6-Dimethyl-1-[2-(4-morpholinyl)ethyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid diethyl diester
CAS No. 77590-96-6
项目整合开发状态: Biological Testing<...
参考文献标题:Flordipine
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Thorpe,P.J.
参考来源:Drugs Fut 1983,8(9),770

Fluconazole, UK-49858, Zoltec, Loitin, Triflucan, Diflucan

氟康唑Chemical Name: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol; alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol; 2,4-Difluoro-alpha,alpha...
参考文献标题:Triazoles
文献作者:Richardson,K.(Pfizer Inc.)
参考来源:GB 2099818; US 4404216

Flutazolam

氟恶唑兰Chemical Name: 10-Chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
CAS No. 27060-91-9
项目整合开发状态: Biological Testing
项目研究机构...
参考文献标题:Flutazolam
文献作者:Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1977,2(12),803

Fluperlapine, NB-106689

氟扑来平Chemical Name: 3-Fluoro-6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine; 3-Fluoro-6-(4-methyl-1-piperazinyl)morphanthridine
CAS No. 67121-76-0
项目整合开发状态: Biological Testing
项目研究机构: Novar...
参考文献标题:Fluperlapine
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(5),326

Flutoprazepam, KB-509, Restas

氟托西泮Chemical Name: 7-Chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS No. 25967-29-7
项目整合开发状态: Withdrawn
项目研究机构: Kanebo (Originator)
合成路线:The reac...
参考文献标题:Process for producing benzodiazepine derivatives
文献作者:Yamamoto,H.; et al.(Sumitomo Chemical Co.,Ltd.)
参考来源:US 3632574

Flutrimazole, UR-4056, Flusporan, Cutiman, Micetal

氟曲马唑Chemical Name: 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
CAS No. 119006-77-8
项目整合开发状态: Launched-1995
项目研究机构: Uriach (Originator), Biohorm (Licensee), Menarini (License...
参考文献标题:Synthesis and antifungal activity of a series of difluorotritylimidazoles
文献作者:Forn,J.; Bartrol? J.; Alguer? M.; Boncompte,E.
参考来源:Arzneim-Forsch Drug Res 1992,42(6),832

Fluticasone propionate, FN-25, CCI-18781, Fluspiral, Flovent Diskus, Flusonal, Flovent DPI, Fluxonal, Flonase, Flunase, Flovent, Flixotide, Flutide, Cutivate, Flixonase

氟替卡松丙酸酯Chemical Name: (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester; 6alpha,9-Difluoro-11beta,1...
参考文献标题:Androstane 17beta-carbothioates
文献作者:Phillips,G.H.; Bain,B.M.; Williamson,C.; Steeples,I.P.; Laing,S.B.(Glaxo Wellcome plc)
参考来源:GB 2088877; NL 8100707; US 4335121

Flurbiprofen axetil, FP-83, Ropion

氟比洛芬酯Chemical Name: (?-2-(2-Fluoro-4-biphenylyl)propionic acid 1-(acetoxy)ethyl ester; (?-2-Fluoro-alpha-methyl-4-biphenylacetic acid 1-(acetoxy)ethyl ester
CAS No. 91503-79-6
项目整合开发状态: Launched...
参考文献标题:Ester of flurbiprofen and emulsion containing the same
文献作者:Mizushima,Y.; Uchida,K.; Masumoto,S.; Tohno,M.; Hashimoto,Y.; Yokoyama,K.; Okamoto,H.; Nabeta,K.; Suyama,T.(Welfide Corporation)
参考来源:EP 0129435; JP 1985001122; US 4613505

Froxiprost, Ono-995

氟氧前列素Chemical Name: 16-(3-Trifluoromethylphenoxy)-17,18,19,20-tetranor-trans-DELTA2-PGF2alpha methyl ester; Methyl 9alpha,11alpha,15alpha-trihydroxy-16-(3-trifluoromethylphenoxy)-17,18,19,20-tetranorp...
参考文献标题:ONO-995
文献作者:Castar,J.; Riberos,J.
参考来源:Drugs Fut 1980,5(10),499

Flomoxef sodium, FMOX, 6315-S, Flumarin

氟氧头孢钠Chemical Name: (-)-(6R,7R)-7-[2-(Difluoromethylthio)acetamido]-7-methoxy-3-[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thiomethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt...
参考文献标题:Flomoxef sodium
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(6),452