项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Binifibrato, Binifibrate, WAC-104, Antopal retard, Biniwas

比尼贝特Chemical Name: 2-(4-Chlorophenoxy)-2-methylpropionic acid 1,3-bis(pyridin-3-ylcarbonyloxy)propan-2-ol ester
CAS No. 69047-39-8
项目整合开发状态: Launched-1987
项目研究机构: Soc. Esp. Esp. Farmaco-Terap...
参考文献标题:WAC-104
文献作者:Castar,J.
参考来源:Drugs Fut 1979,4(9),681

Bizelesin, NSC-615291, U-77779

比折来新Chemical Name: (S,S)-6,6'-[Carbonylbis(5-imino-1H-indole-2-carbonyl)]bis[8-(chloromethyl)-1-methyl-3,6,7,8-tetrahydrobenzo[1,2-b:4,3-b']dipyrrol-4-ol]; (S,S)-1,3-Bis[2-[1-(Chloromethyl)-5-hydroxy-...
参考文献标题:Novel CC-1065 analogs having two CPI subunits
文献作者:Kelly,R.C.; Aristoff,P.A.(Pharmacia Corp.)
参考来源:EP 0359454; JP 1992500664; WO 9002746

Bilastine

比拉斯汀Chemical Name: 2-[4-[2-[4-[1-(2-Ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylproionic acid
CAS No. 202189-78-4
项目整合开发状态: Phase III
项目研究机构: FAES (Originator)
合成路线:...
参考文献标题:Benzimidazole derivs.with antihistaminic activity
文献作者:Orjales,A.; Rubio,V.; Bordell,M.(FAES)
参考来源:EP 0818454; ES 2124167; JP 1998059961; US 5877187

Bisaramil hydrochloride, RGH-2957, YUTAC

比沙雷米盐酸盐比沙雷米Chemical Name: 3-Ethyl-7-methyl-9alpha-(4'-chlorobenzoyloxy)-3,7-diazabicyclo[3.3.1]nonane monohydrochloride
CAS No. 96480-44-3, 89367-99-7 (diHCl), 89194-77-4 (free base)
项目整合开发状态: P...
参考文献标题:YUTAC
文献作者:Lapis,E.
参考来源:Drugs Fut 1985,10(10),837

Bisantrene hydrochloride, NSC-337766, ADD, CL-216942, Cyabin, Zantrene

比生群二盐酸盐比生群 Chemical Name: 9,10-Anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride; 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone) dihydrochloride...
参考文献标题:CL-216,942
文献作者:Hillier,K.; Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1981,6(12),762

CKD-732

比罗尼布Chemical Name: 3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2(E)-propenoic acid (3R,4S,5S,6R)-4-[2(R)-methyl-3(R)-(3-methyl-2-butenyl)oxiran-2-yl]-5-methoxy-1-oxaspiro[2.5]oct-6-yl ester; 6-O-[3-[4-[2-(D...
参考文献标题:Fumagillol derivs.and processes for preparing the same
文献作者:Chun,H.S.; Choi,N.S.; Lee,S.J.; Han,C.K.; Hong,C.I.; Hong,R.K.; Kim,J.W.; Moon,S.K.; Ahn,S.K.(Chong Kun Dang Corp.)
参考来源:US 6063812; WO 9959986

Bimosiamose, TBC-1269

比莫西糖Chemical Name: 3,3'-(Hexane-1,6-diyl)bis[6-(alpha-D-mannopyranosyloxy)-3,1-phenylene]bis(phenylacetic acid); 3',3'''-(1,6-Hexanediyl)bis[6'-(alpha-D-mannopyranosyloxy)[1,1'-biphenyl]-3-acetic acid...
参考文献标题:Di- and trivalent small molecule selectin inhibitors
文献作者:Kogan,T.P.; Dupre,B.; Scott,I.L.; Bui,H.; Wheeler,K.L.; Keller,K.M.; Kassir,J.M.(Texas Biotechnology Corp.)
参考来源:JP 1999508885; WO 9701335

Biapenem, CL-186815, L-627, LJC-10627, Omegacin

比阿培南Chemical Name: (1R,5S,6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolio-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapenem-3-carboxylate
CAS No. 120410-24-4
项目整合开发状态: Launched-2002 参考文献标题:(1R,5S,6S)-2-(Substd.thio)-6-[(R)-1-hydroxy-ethyl]-1-methyl-carbapenem-3-carboxylic-acid derivatives
文献作者:Kumagai,T.; Matsunaga,H.; Machida,Y.; Nagase,Y.; Hikida,M.; Nagao,Y.(Lederle (Japan),Ltd.)
参考来源:AU 8814428; EP 0289801; JP 1989025779; US 4925836

Bimatoprost, AGN-192024, Lumigan

比马前列素Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-N-ethyl-5-heptenamide; 17-Phenyl-18,19,20-trinorprostaglandin F2alpha ethylamide; (5Z,9alp...
参考文献标题:Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivs.as therapeutic agents
文献作者:Woodward,D.F.; Andrews,S.W.; Burk,R.M.; Garst,M.E.(Allergan,Inc.)
参考来源:EP 0660716; JP 1996501310; US 5352708; WO 9406433

Motretinide, Ro-11-1430, Tasmaderm

毛替垂尼Chemical Name: all-trans-N-Ethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenamide
CAS No. 56281-36-8
项目整合开发状态: Launched-1980
项目研究机构: Roche (Originator), Gebro Pha...
参考文献标题:Motretinide
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1978,3(2),126