Bimatoprost, AGN-192024, Lumigan
比马前列素Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-N-ethyl-5-heptenamide; 17-Phenyl-18,19,20-trinorprostaglandin F2alpha ethylamide; (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinorprosta-5,13-dienoic acid ethylamide
CAS No. 155206-00-1
项目整合开发状态: Launched-2001
项目研究机构: Allergan (Originator), Senju (Licensee)
合成路线:The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II),which is finally treated with ethylamine in methanol at 80-5 C.
📌 参考资料/链接：
参考文献标题:Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivs.as therapeutic agents
文献作者:Woodward,D.F.; Andrews,S.W.; Burk,R.M.; Garst,M.E.(Allergan,Inc.)
参考来源:EP 0660716; JP 1996501310; US 5352708; WO 9406433
📄 详细内容
合成路线:The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II),which is finally treated with ethylamine in methanol at 80-5 C.
参考文献标题:Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivs.as therapeutic agents
文献作者:Andrews,S.W.; Burk,R.M.; Garst,M.E.; Woodward,D.F.(Allergan,Inc.)
参考来源:US 5607978
合成路线:The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II),which is finally treated with ethylamine in methanol at 80-5 C.
参考文献标题:Bimatoprost
文献作者:Rabasseda,X.; Castar,J.; Sorbera,L.A.; Leeson,P.A.
参考来源:Drugs Fut 2001,26(5),433
产品链接: CAS No. 155206-00-1››