Flurbiprofen axetil, FP-83, Ropion
氟比洛芬酯Chemical Name: (?-2-(2-Fluoro-4-biphenylyl)propionic acid 1-(acetoxy)ethyl ester; (?-2-Fluoro-alpha-methyl-4-biphenylacetic acid 1-(acetoxy)ethyl ester
CAS No. 91503-79-6
项目整合开发状态: Launched-1992
项目研究机构: Kaken (Originator), Mitsubishi Pharma (Originator)
合成路线:By esterification of 2-(2-fluoro-4-biphenylyl)propionic acid (I) with 1-(acetoxy)ethyl chloride (II) or 1-(acetoxy)ethyl bromide (III) by means of anhydrous K2CO3 in DMF or by transesterification of the acid (I) and ethylidene diacetate (IV) in benzene.
📌 参考资料/链接：
参考文献标题:Ester of flurbiprofen and emulsion containing the same
文献作者:Mizushima,Y.; Uchida,K.; Masumoto,S.; Tohno,M.; Hashimoto,Y.; Yokoyama,K.; Okamoto,H.; Nabeta,K.; Suyama,T.(Welfide Corporation)
参考来源:EP 0129435; JP 1985001122; US 4613505
📄 详细内容
合成路线:By esterification of 2-(2-fluoro-4-biphenylyl)propionic acid (I) with 1-(acetoxy)ethyl chloride (II) or 1-(acetoxy)ethyl bromide (III) by means of anhydrous K2CO3 in DMF or by transesterification of the acid (I) and ethylidene diacetate (IV) in benzene.
参考文献标题:Biphenylpropionic acid deriv.,process for preparing the same and pharmaceutical compsn.containing the same
文献作者:Uchida,K.; Masumoto,S.; Tohno,M.; Mimura,M.; Okumura,M.; Ichikawa,K.; Matsumura,M.(Kaken Pharmaceutical Co.,Ltd.)
参考来源:EP 0103265; US 5196567
合成路线:By esterification of 2-(2-fluoro-4-biphenylyl)propionic acid (I) with 1-(acetoxy)ethyl chloride (II) or 1-(acetoxy)ethyl bromide (III) by means of anhydrous K2CO3 in DMF or by transesterification of the acid (I) and ethylidene diacetate (IV) in benzene.
参考文献标题:Liposomal Flurbiprofen Axetil
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1992,17(9),788
合成路线:By esterification of 2-(2-fluoro-4-biphenylyl)propionic acid (I) with 1-(acetoxy)ethyl chloride (II) or 1-(acetoxy)ethyl bromide (III) by means of anhydrous K2CO3 in DMF or by transesterification of the acid (I) and ethylidene diacetate (IV) in benzene.
参考文献标题:Method for the preparation of 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate
文献作者:Mimura,M.; Uchida,K.; Ieda,T.; et al.
参考来源:JP 89211550
产品链接: CAS No. 91503-79-6››