Flordipine, RHC-2906
氟地平Chemical Name: 2,6-Dimethyl-1-[2-(4-morpholinyl)ethyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid diethyl diester
CAS No. 77590-96-6
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:By cyclization of ethyl acetoacetate (I) with 2-trifluoromethylbenzaldehyde (II) and N-(2-aminoethyl)morpholine (III) in refluxing ethanol
合成路线:By condensation of diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (IV) with N-(2-chloroethyl)morpholine (V) by means of NaH in hot DMF - toluene
📌 参考资料/链接：
参考文献标题:Flordipine
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Thorpe,P.J.
参考来源:Drugs Fut 1983,8(9),770
📄 详细内容
合成路线:By cyclization of ethyl acetoacetate (I) with 2-trifluoromethylbenzaldehyde (II) and N-(2-aminoethyl)morpholine (III) in refluxing ethanol
合成路线:By condensation of diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (IV) with N-(2-chloroethyl)morpholine (V) by means of NaH in hot DMF - toluene
参考文献标题:
文献作者:Loev,B.; Shroff,J.R.(USV Pharmaceutical Corp.)
参考来源:BE 888327; DE 3109794; FR 2480284; GB 2073739; JP 81158762; US 4258042
产品链接: CAS No. 77590-96-6››