项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Manzamine A

氢溴酸加兰它敏Chemical Name: 24-(9H-Pyrido[3,4-b]indol-1-yl)-2,3,5,6,7,8,11,12,13,13a,15,16,17,18,20a,21-hexadecahydro-1,13-etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13-ol 参考文献标题:Enantioselective total synthesis of ircinal A and related manzamine alkaloids
文献作者:Martin,S.F.; et al.
参考来源:J Am Chem Soc 1999,121(4),866

Nitalapram, Citalopram hydrobromide, Lu-10-171B, ZD-211, Lu-10-171(free base), Sepram, Apertia, Lupram, Cipram, Prisdal, Celexa, Elopram, Seropram, Cipramil

氢溴酸西酞普兰西酞普兰 Chemical Name: 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-phthalancarbonitrile monohydrobromide; 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile m...
参考文献标题:Method for the preparation of citalopram
文献作者:Ellegaard,P.; Petersen,H.; Rock,M.H.(H.Lundbeck A/S)
参考来源:WO 0012044

Darifenacin hydrobromide, UK-88525(free base), UK-88525-04, Emselex, Enablex

氢溴酸达非那新达非那新 Chemical Name: 2-[1-[2-(2,3-Dihydrobenzofuran-5-yl)ethyl]pyrrolidin-3(S)-yl]-2,2-diphenylacetamide hydrobromide
CAS No. 133099-07-7, 133099-04-4 (free base)
项目整合开发状态: Registered-200...
参考文献标题:Pyrrolidine derivs
文献作者:Cross,P.E.; Mackenzie,A.R.(Pfizer Inc.)
参考来源:AU 9051402; EP 0388054; JP 1990282360; JP 1995149640; US 5096890

Ungerimine acetate, Ungeremine acetate, Lycobetaine acetate, AT-1840

氧化石蒜碱乙酸盐Chemical Name: 2-Hydroxy-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium acetate
CAS No. 61221-41-8, 2121-15-5 (as bromide), 2121-17-7 (as picrate), 2121-16-6 (chloride), 21...
参考文献标题:Lycobetaine acetate
文献作者:Ru-yun,J.
参考来源:Drugs Fut 1983,8(2),118

Oxitropium bromide, BA-253, Oxivent

氧托溴铵Chemical Name: (3s,6R,7S,8r)-8-Ethyl-3-[(S)-tropoyloxy]-6,7-epoxytropanium bromide
CAS No. 30286-75-0
项目整合开发状态: Launched-1983
项目研究机构: Boehringer Ingelheim (Originator), Nippon Boehringer ...
参考文献标题:Oxitropium bromide
文献作者:Dharma,A.P.
参考来源:Drugs Fut 1979,4(2),117

Ofloxacin, Hoe-280, DL-8280, Exocin, Exocine, Ocuflox, Floxin, Tarivid

氧氟沙星Chemical Name: (?-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
CAS No. 82419-36-1
项目整合开发状态: Launched-1985
项目研究机构: ...
参考文献标题:Benzoxazine derivs.
文献作者:Hayakawa,I.; Hiramitsu,T.; Tanaka,Y.(Daiichi Pharmaceutical Co.,Ltd.)
参考来源:EP 0047005; US 4382892

Oxandrolone, NSC-67068, SC-11585, Hepandrin, Lonavar, Oxandrin, Anavar

氧甲氢龙Chemical Name: 17-beta-Hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one
CAS No. 53-39-4
项目整合开发状态: Launched-1966
项目研究机构: Pfizer (Originator), Savient Pharmaceuticals (Originator), Abbot...
参考文献标题:Process for the synthesis of oxandrolone
文献作者:Cabaj,J.E.; Kairys,D.L.; Zizelman,P.M.
参考来源:WO 02100881

Benoxaprofen, Oraflex

氧苯恶唑丙酸Chemical Name: 2-[2-(4-Chlorophenyl)benzoxazol-5-yl]propionic acid
CAS No. 51234-28-7
项目整合开发状态: Withdrawn-1980
项目研究机构: Lilly (Originator)
合成路线:The Sandmeyer reaction of 4-aminophenyl...
参考文献标题:Benzoxazole derivatives
文献作者:Dunwell,D.W.; et al.(Lilly Industries Ltd.)
参考来源:DE 2324443; ES 414863; FR 2184966; FR 2284592; GB 1435721; JP 49054363; JP 56167645; US 3912748

Amrinone, Win-40680, Cordarex, Amcoral, Cartonic, Wincoram, Inocor(lactate)

氨力农Chemical Name: 5-Amino-(3,4'-bipyridin)-6(1H)-one; 3-Amino-5-(4-pyridinyl)-2(1H)pyridinone
CAS No. 60719-84-8
项目整合开发状态: Launched-1983
项目研究机构: Sanofi-Aventis (Originator), Yamanouchi (Licen...
参考文献标题:3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
文献作者:Lesher,G.Y.; Opalka,C.J.(Sanofi-Synthabo)
参考来源:US 4004012; ZA 7606042

Amipizone, LU-23051

氨匹宗Chemical Name: 2-Chloro-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]propionamide
CAS No. 69635-63-8
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compound can be obtained...
参考文献标题:
文献作者:Lebkuecher,R.; Thyes,M.; Koening,H.; Lehmann,H.D.; Gries,J.; Lenke,D.; Kunze,J.
参考来源:CA 1108614; DE 2727481; EP 113; JP 7909289