Amipizone, LU-23051
氨匹宗Chemical Name: 2-Chloro-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]propionamide
CAS No. 69635-63-8
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compound can be obtained by two different ways:1) The acylation of 2-(4-aminobenzoyl)propionic acid (I) with 2-chloropropionyl chloride (II) in hot toluene gives 2-[4-[(2-chloropropionyl)amino]benzoyl]propionic acid (III),which is then cyclized with hydrazine in refluxing ethanol.2) By acylation of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (IV) with 2-chloropropionyl chloride (II) in refluxing benzene.
📌 参考资料/链接：
参考文献标题:
文献作者:Lebkuecher,R.; Thyes,M.; Koening,H.; Lehmann,H.D.; Gries,J.; Lenke,D.; Kunze,J.
参考来源:CA 1108614; DE 2727481; EP 113; JP 7909289
📄 详细内容
合成路线:This compound can be obtained by two different ways:1) The acylation of 2-(4-aminobenzoyl)propionic acid (I) with 2-chloropropionyl chloride (II) in hot toluene gives 2-[4-[(2-chloropropionyl)amino]benzoyl]propionic acid (III),which is then cyclized with hydrazine in refluxing ethanol.2) By acylation of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (IV) with 2-chloropropionyl chloride (II) in refluxing benzene.
参考文献标题:Amipizone
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1982,7(10),714
产品链接: CAS No. 69635-63-8››