Oxitropium bromide, BA-253, Oxivent

氧托溴铵Chemical Name: (3s,6R,7S,8r)-8-Ethyl-3-[(S)-tropoyloxy]-6,7-epoxytropanium bromide
CAS No. 30286-75-0
项目整合开发状态: Launched-1983
项目研究机构: Boehringer Ingelheim (Originator), Nippon Boehringer Ingelheim (Originator)
合成路线:Compound can be prepared in three steps starting from (-)-scopalamine (hyoscine) (I) by demethylation of (-)-scopolamine with phosgene or potassium permanganate,by alkylation of the resulting (-)-norscopolamine (II) with ethylbromide (A) by means of sodium carbonate,and by quaternization of the resulting (-)-N-ethyl-norscopolamine (III) with methylbromide yielding Ba-253-BR.