项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Amfenac sodium, AHR-5850D, Fenazox, Fenamate

氨芬酸钠氨芬酸 Chemical Name: 2-Amino-3-benzoylbenzeneacetic acid sodium salt monohydrate
CAS No. 61618-27-7, 51579-82-9 (free acid)
项目整合开发状态: Launched-1985
项目研究机构: Meiji Seika (Originator)
合成路线...
参考文献标题:Anti-inflammatory methods using 2-amino-3-(5- and 6-)benzoylphenyl acetic acids,esters and metal salts thereof and the compounds
文献作者:Welstead,W.J.Jr.; Moran,H.W.(A.H.Robins Co.Inc.)
参考来源:CA 1012979; DE 2324768; FR 2184934; GB 1521097; US 4045576

Nafidimide, Amonafide, CGX-571, M-FA-142, BIDA, NSC-308847, Xanafide, Quinamed

氨萘非特Chemical Name: 3-Amino-N-[2-(dimethylamino)ethyl]naphthalimide; 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[d,e]isoquinoline-1,3(2H)-dione
CAS No. 69408-81-7
项目整合开发状态: Phase II
项目研究机构: Abb...
参考文献标题:Naphthalimides,process for their preparation and pharmaceutical compositions containing them
文献作者:Bra馻,M.F.; Martinez Sanz,A.; P閞ez Alvarez-Ossorio,R.; Martinez Roldan,C.; Rodan Fernandez de Gamboa,C.(Made Labs.)
参考来源:DE 2823987

Aminoglutethimide, AG-1, Orimeten, Cytadren

氨鲁米特Chemical Name: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
CAS No. 125-84-8
项目整合开发状态: Launched-1981
项目研究机构: Novartis (Originator)
合成路线:An improved procedure for the large-scale prepa...
参考文献标题:Production of (R)-aminogluthimide: A new route from 1-chloro-4-nitrobenzene
文献作者:Bunegar,M.J.; et al.
参考来源:Org Process Res Dev 1999,3(6),442

Azetirelin dihydrate, YM-14673

氮替瑞林Chemical Name: Nalpha-[[(S)-4-Oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate; Nalpha-[(S)-2-Azetidinone-4-carbonyl]-L-histidyl-L-prolinamide dihydrate
CAS No. 95729-65-0 (anhydro...
参考文献标题:4-Substituted-2-azetidinone compounds,process for producing them and medicaments containing them
文献作者:Iwamoto,H.; Yoshida,M.; Yamamoto,M.; Tamura,T.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:AU 8426100; EP 0123444; ES 86279; ES 864209; JP 84225182; JP 85115577; JP 85115578; US 4564609; US 4636567; US 610821

Nonachlazine, Azaclorzine, AY-25239(hydrochloride)

氮氯嗪Chemical Name: 2-Chloro-10-[3-(hexahydropyrrolo[1,2-a]pyrazin-2[1H]-yl)propionyl]-phenothiazine; 2'-Chloro-10'-[beta-N-(1,4-diazabicyclo-[4,3-0]-propionyl]phenothiazine
CAS No. 49864-70-2, 49780...
参考文献标题:Azaclorzine
文献作者:Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1976,1(4),157

Lortalamine, LM-1404

氯他拉明Chemical Name: (?-(4aR*,10R*,10aS*)-8-Chloro-1,2,3,4,10,10a-hexahydro-2-methyl-4a,10-(iminoethano)-4aH-[1]benzopyrano[3,2-c]pyridin-12-one; (?-(4aR*,10R*,10aS*)-4a-Amino-8-chloro-2-methyl-1,2,3,4,...
参考文献标题:1,2,4-Triazine derivs.,process for preparing such cpds.,pharmaceutical compsns.and intermediates utilized for this process
文献作者:Baxter,M.G.; Elphick,A.R.; Miller,A.A.; Sawyer,D.A.(Glaxo Wellcome plc)
参考来源:CA 1133938; EP 0021121

Clovoxamine, DU-13811

氯伏胺Chemical Name: p-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime; 1-(4-Chlorophenyl)-5-methoxy-1-pentanone (E)-O-(2-aminoethyl)oxime
CAS No. 54739-19-4
项目整合开发状态: Phase III
项目研究机构: ...
参考文献标题:Clovoxamine
文献作者:Dharma,A.P.
参考来源:Drugs Fut 1979,4(8),563

Cloricromene, AD-6, Proendotel

氯克罗孟Chemical Name: 8-Chloro-3-(beta-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycoumarin; 2-[8-Chloro-7-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yloxy]acetic acid ethyl ester 参考文献标题:AD-6
文献作者:Castar,J.; Hillier,K.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1979,4(10),701

Nitidine chloride, NSC-146397(anhydrous)

氯化两面针碱氯化两面针碱 Chemical Name: 2,3-Dimethoxy-12-methyl[1,3]benzodioxo[5,6-c]phenanthridinium chloride dihydrate; 8,9-Dimethoxy-5-methyl-2,3-methylenedioxybenzo[c]phenanthridinium chloride dihydrate
C...
参考文献标题:Nitidine Chloride
文献作者:Zee-Cheng,R.K.-Y.; Cheng,C.C.
参考来源:Drugs Fut 1985,10(2),124

Ditercalinium chloride dihydrochloride, NSC-366241(tetramethanesulfonate), RB-1607, NSC-335153

氯化地特卡里Chemical Name: 2,2'-[(4,4'-Bipiperidine)-1,1'-diyldiethylene]bis(10-methoxy-7H-pyrido[4,3-c]carbazolium) dichloride dihydrochloride
CAS No. 74517-42-3 (free base)
项目整合开发状态: Biological Test...
参考文献标题:Ditercalinium Chloride
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1985,10(2),116