Azetirelin dihydrate, YM-14673
氮替瑞林Chemical Name: Nalpha-[[(S)-4-Oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate; Nalpha-[(S)-2-Azetidinone-4-carbonyl]-L-histidyl-L-prolinamide dihydrate
CAS No. 95729-65-0 (anhydrous)
项目整合开发状态: Phase III
项目研究机构: Yamanouchi (Originator)
合成路线:By condensation of 4-oxoazetidine-2(S)-carboxylic acid (I) with L-histidyl-L-prolinamide (II) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxy-1,2,3-benzotriazole (HOBT) in DMF.
📌 参考资料/链接：
参考文献标题:4-Substituted-2-azetidinone compounds,process for producing them and medicaments containing them
文献作者:Iwamoto,H.; Yoshida,M.; Yamamoto,M.; Tamura,T.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:AU 8426100; EP 0123444; ES 86279; ES 864209; JP 84225182; JP 85115577; JP 85115578; US 4564609; US 4636567; US 610821
📄 详细内容
合成路线:By condensation of 4-oxoazetidine-2(S)-carboxylic acid (I) with L-histidyl-L-prolinamide (II) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxy-1,2,3-benzotriazole (HOBT) in DMF.
参考文献标题:Novel crystals of Nalpha-[[(S)-4-oxo-2-azetidinyl]carbenyl]-L-histidyl-L-prolinamide and process for producing the crystals
文献作者:Tamura,T.; Matsuda,H.; Yoshida,M.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:AU 8666308; EP 0225796; JP 87234094
合成路线:By condensation of 4-oxoazetidine-2(S)-carboxylic acid (I) with L-histidyl-L-prolinamide (II) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxy-1,2,3-benzotriazole (HOBT) in DMF.
参考文献标题:AZETIRELIN DIHYDRATE < Prop INNM >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(3),203
产品链接: CAS No. 95729-65-0››