Flunoxaprofen, RV-12424, MK-830, Priaxim

氟诺洛芬Chemical Name: (S)-(?-2-(4-Fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid
CAS No. 66934-18-7
项目整合开发状态: Launched-1986
项目研究机构: Ravizza (Originator)
合成路线:The acidic hydrolysis of 3-nitro-4-hydroxyphenyl-alpha-methylacetonitrile (I) gives 3-nitro-4-hydroxyphenyl-alpha-methylacetic acid (II),which is converted to 3-amino 4-hydroxyphenyl-alpha-methylacetic acid (III) by catalytic hydrogenation.The condensation of (III) with 4-fluorobenzoyl chloride yields 3-(4-fluoro benzamido)-4-hydroxyphenyl-alpha-methylacetic acid (IV),which is cyclized in acidic medium to give 2-(4-fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid (V).The racemic (V) was optically resolved by N-methyl-D-glucamine,yielding S-(+)-2-(4-fluorophenyl)-alpha-methyl-5-benzoxazoleacetic acid.