Cymserine
氨基酸,N-[4-(1-甲基乙基)苯基]-,(3aS,8aR)-1,2,3,3a,8,8a-六氢-1,3a,8-三甲基吡咯罗[2,3-b]吲哚-5-伊酯Chemical Name: N-[4-(1-Isopropylphenyl)carbamic acid (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ylester
CAS No. 145209-39-8
项目整合开发状态: Preclinical
项目研究机构: Axonyx (Originator), National Institutes of Health (Codevelopment)
合成路线:Hydrolysis of physostigmine (I) with either NaOMe in ethanol or NaOBu in refluxing butanol (better yield) gives eseroline (II),which is condensed with phenyl isocyanate (III) by means of NaOMe in benzene,Na in benzene or Na in ether/benzene.
合成路线:The title carbamate was prepared by condensation of (-)-eseroline (I) with 4-isopropylphenyl isocyanate in Et2O in the presence of a catalytic amount of Na.
📌 参考资料/链接：
参考文献标题:Substd.phenserines as specific inhibitors of acetylcholinesterase
文献作者:Brossi,A.; Brzostowska,M.; Rapoport,S.I.; Greig,N.; He,X.-S.(US Department of Health & Human Services)
参考来源:EP 0606366; JP 1995503703; US 5171750; WO 9306105
📄 详细内容
合成路线:Hydrolysis of physostigmine (I) with either NaOMe in ethanol or NaOBu in refluxing butanol (better yield) gives eseroline (II),which is condensed with phenyl isocyanate (III) by means of NaOMe in benzene,Na in benzene or Na in ether/benzene.
合成路线:The title carbamate was prepared by condensation of (-)-eseroline (I) with 4-isopropylphenyl isocyanate in Et2O in the presence of a catalytic amount of Na.
参考文献标题:Phenylcarbamates of (-)-eseroline,(-)-N1-noreseroline and (-)-physovenol: Selective inhibitors of acetyl and,or butyrylcholinesterase
文献作者:Brzostowska,M.; et al.
参考来源:Med Chem Res 1992,2(4),238
产品链接: CAS No. 145209-39-8››