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项目整合精选>>>Amlexanox, Amoxanox, CHX-3673, AA-673, OraDisc A, Aptheal, Apthera, OraRinse, Aphthasol, Elics, Solfa
Amlexanox, Amoxanox, CHX-3673, AA-673, OraDisc A, Aptheal, Apthera, OraRinse, Aphthasol, Elics, Solfa
氨来呫诺Chemical Name: 2-Amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid; 2-Amino-7-isopropyl-1-azaxanthone-3-carboxylic acid
CAS No. 68302-57-8
项目整合开发状态: Launched-1987
项目研究机构: Senju (Originator), Takeda (Originator), Access Pharmaceuticals (Licensee), Esteve (Licensee), GlaxoSmithKline (Licensee), Paladin (Licensee), Strakan (Licensee), Wyeth Pharmaceuticals (Licensee), Zambon (Licensee)
合成路线:The reaction of 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile (I) with morpholine (A) and DMF in hot water gives 2-amino-6-isopropyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde (II),which is cyclized with ethyl cyanoacetate (III) by means of piperidine (B) in refluxing ethanol yielding ethyl 2-amino-7-isopropyl-1-azaxanthone-3-carboxylate (IV).Finally,this compound is saponified by a treatment with sulfuric acid in refluxing acetic acid water.
📌 参考资料/链接：
参考文献标题:1-Azaxanthone-3-carboxylic acid
文献作者:Nohara,A.; Sugihara,H.; Ukawa,K.(Takeda Chemical Industries,Ltd.)
参考来源:BE 0864647; DE 2809720; FR 2383185; GB 1597024; GB 1597025; JP 78111096; JP 78111097; JP 7988298; US 4143042; US 4255576; US 4299963
📄 详细内容
合成路线:The reaction of 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile (I) with morpholine (A) and DMF in hot water gives 2-amino-6-isopropyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde (II),which is cyclized with ethyl cyanoacetate (III) by means of piperidine (B) in refluxing ethanol yielding ethyl 2-amino-7-isopropyl-1-azaxanthone-3-carboxylate (IV).Finally,this compound is saponified by a treatment with sulfuric acid in refluxing acetic acid water.
参考文献标题:AA-673
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(5),311
产品链接: CAS No. 68302-57-8››