项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Nesosteine sodium, CO-1177

奈索司坦 Chemical Name: 2-(3-Thiazolidinylcarbonyl)benzoic acid sodium salt
CAS No. 84210-62-8, 84233-61-4 (free acid)
项目整合开发状态: Phase III
项目研究机构: Camillo Corvi (Originator)
合成路线:By reaction ...
参考文献标题:Thiazolidine derivatives and their mucolytic compositions and methods
文献作者:Mora Camillo,C.(Camillo Corvi SpA)
参考来源:BE 0892516; DE 3215610; FR 2505834; GB 2098215; JP 57162375; US 4477458

Nemonapride, Emonapride, YM-09151-2, Emilace

奈莫必利 Chemical Name: (?-cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide; (?-cis-N-(1-Benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide
CAS No. ...
参考文献标题:Benzamide derivatives
文献作者:Takashima,M.; Iwanami,S.; Usuda,S.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:BE 0885435; FR 2444461; US 4210660

Quinupristin mesilate, RP-57669

奎奴普丁Chemical Name: N-(3-Hydroxy-2-pyridylcarbonyl)-(S)-threonyl-(R)-(alpha-aminobutyryl)-(S)-prolyl-[N-methyl-4-(dimethylamino)-(S)-phenylalanyl]-[4-oxo-5(R)-[quinuclidin-3(S)-ylthiomethyl]-(S)-homop...
参考文献标题:Pristinaymcin IA or viginiamycin derivs.and their preparation
文献作者:Bastart,J.P.; Paris,J.M.; Radisson,X.(Aventis SA)
参考来源:EP 0432029

Oxepinac

奥昔平酸Chemical Name: 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl)acetic acid
CAS No. 55689-65-1
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in several different ways:1) The ...
参考文献标题:
文献作者:Ueno,K.; et al.
参考来源:BE 818055; DE 2435613; FR 2245356; JP 75108280; JP 75108281; JP 7535179; JP 7535180; JP 7535181

Osanetant, SR-142806((S)-isomer), SR-142801(monoHCl)

奥沙奈坦Chemical Name: N-[1-[3-[1-Benzoyl-3(R)-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-N-methylacetamide
CAS No. 160492-56-8, 173050-51-6 (monoHCl)
项目整合开发状态: Phase II
...
参考文献标题:Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivs.as selective human NK3-receptor antagonists
文献作者:Bichon,D.; Van Broeck,D.; Proietto,V.; Gueule,P.; Emonds-Alt,X.(Sanofi-Synthabo)
参考来源:EP 0673928; FR 2717477; FR 2717478; FR 2719311; JP 1996048669; US 5741910; US 5942523; US 6124316

Oxamisole hydrochloride, PR-879317A

奥沙米索Chemical Name: 2,3,5,6,7,8-Hexahydro-2-phenyl-8,8-dimethoxyimidazo[1,2-a]pyridine hydrochloride
CAS No. 99258-56-7 (free base), 99258-55-6 (monoHCl)
项目整合开发状态: Phase I
项目研究机构: Pennwalt (O...
参考文献标题:Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine
文献作者:Davidson,T.A.; Murray,R.J.(Pennwalt Corp.)
参考来源:EP 0150255; US 4507481

Orbofiban acetate, CS-511, SC-57099B

奥波非班奥波非班乙酸盐Chemical Name: N-[[1-(4-Amidinophenyl)-2-oxo-3(S)-pyrrolidinyl]carbamoyl]-beta-alanine ethyl ester monoacetate
CAS No. 163250-91-7, 163250-90-6 (free base), 165800-05-5 (hydrate(4:1))<...
参考文献标题:Process for the preparation of amidino phenyl pyrrolidine betal-alanine urea analogs
文献作者:Abood,N.A.; Flynn,D.L.; Laneman,S.A.; Nosal,R.; Schretzman,L.A.(Pharmacia Corp.)
参考来源:US 5484946

T-3912

奥泽沙星Chemical Name: 1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)pyridin-3-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No. 245765-41-7
项目整合开发状态: Preclinical
项目研究机构: Toyama (Orig...
参考文献标题:Quinolonecarboxylic acid derivs.or salts thereof
文献作者:Hayashi,K.; Yamakawa,T.; Kawafuchi,H.; Kito,T.; Mitsuyama,J.; Kuroda,H.(Toyama Chemical Co.,Ltd.)
参考来源:EP 1070713; WO 9951588

AVE-8062, RPR-258062A, AVE-8062A, CS-39-L-Ser.HCl, AC-7700

奥瑞布林Chemical Name: N-[2-Methoxy-5-[2(Z)-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide hydrochloride; 2(S)-Amino-3-hydroxy-N-[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]propanamide h...
参考文献标题:Stilbene derivs.and pharmaceutical compsns.containing them
文献作者:Hatanaka,T.; Ohsumi,K.; Tsuji,T.; Nihei,Y.; Nakagawa,R.; Ohishi,K.(Ajinomoto Co.,Inc.)
参考来源:CA 2171275; EP 0731085; JP 1996301831; US 5674906

Otamixaban, FXV-673

奥米沙班Chemical Name: 2(R)-(3-Amidinobenzyl)-3(R)-[4-(1-oxidopyridin-4-yl)benzamido]butyric acid methyl ester
CAS No. 193153-04-7, 219672-50-1 (undefined isomer, HCl salt)
项目整合开发状态: Clinical
项目...
参考文献标题:Substd.N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
文献作者:Guertin,K.R.; Klein,S.I.; Spada,A.P.(Aventis Pharma SA)
参考来源:EP 0906094; JP 2000502710; US 6080767; WO 9724118