AVE-8062, RPR-258062A, AVE-8062A, CS-39-L-Ser.HCl, AC-7700

奥瑞布林Chemical Name: N-[2-Methoxy-5-[2(Z)-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide hydrochloride; 2(S)-Amino-3-hydroxy-N-[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]propanamide hydrochloride
CAS No. 181816-48-8 (free base)
项目整合开发状态: Phase I
项目研究机构: Ajinomoto (Originator), Aventis Pharma (Licensee)
合成路线:Coupling of (Z)-1-(3-amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)- ethene (I) with N-Fmoc-O-acetyl-L-serine (II) in the presence of DCC and HOBt provided the corresponding serineamide (III).Further deprotection of Fmoc and acetyl groups with NaOH furnished the title compound.