Nemonapride, Emonapride, YM-09151-2, Emilace
奈莫必利 Chemical Name: (?-cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide; (?-cis-N-(1-Benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide
CAS No. 93664-94-9, 75272-39-8 (cis-isomer)
项目整合开发状态: Launched-1991
项目研究机构: Yamanouchi (Originator), Negma (Licensee)
合成路线:The reaction of 1-benzyl-2-methyl-3-pyrrolidone (I) with hydroxylamine by means of Na2CO3 in hot ethanol gives the corresponding oxime (II),which is reduced with H2 over Raney-Ni in methanol containing ammonia to afford 1-benzyl-2-methyl-3-aminopyrrotidine (III).Finally,this compound is condensed with 2-methoxy-4-methylamino-5-chlorobenzoic acid (IV) by means of ethyl chlorocarbonate and triethylamine in methylene chloride.
📌 参考资料/链接：
参考文献标题:Benzamide derivatives
文献作者:Takashima,M.; Iwanami,S.; Usuda,S.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:BE 0885435; FR 2444461; US 4210660
📄 详细内容
合成路线:The reaction of 1-benzyl-2-methyl-3-pyrrolidone (I) with hydroxylamine by means of Na2CO3 in hot ethanol gives the corresponding oxime (II),which is reduced with H2 over Raney-Ni in methanol containing ammonia to afford 1-benzyl-2-methyl-3-aminopyrrotidine (III).Finally,this compound is condensed with 2-methoxy-4-methylamino-5-chlorobenzoic acid (IV) by means of ethyl chlorocarbonate and triethylamine in methylene chloride.
参考文献标题:YM-09,151-2
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.; Owen,R.T.
参考来源:Drugs Fut 1982,7(1),47
产品链接: CAS No. 93664-94-9›› 产品链接: CAS No.75272-39-8››