项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Tampramine fumarate, AHR-9377

坦帕明 Chemical Name: N,N-Dimethyl-6-phenyl-11H-pyrido[2,3-b][1,4]benzodiazepine-11-propanamine (E)-butenedioate (1:1); 6-Phenyl-11-[3-(dimethylamino)propyl]-11H-pyrido[2,3-b][1,4]benzodiazepine fumarat...
参考文献标题:Pyridol [1,4] benzodiazepines phenyl-substituees et leurs intermediares,utiles comme medicaments antidepresseurs
文献作者:Taylor,C.R.Jr.(A.H.Robins Co.Inc.)
参考来源:BE 0891666; FR 2515183; JP 58065290

(-)-Epothilone A, Epothilone A

埃博霉素AChemical Name: (4S,7R,8S,9S,13R,14S,16S)-13,14-Epoxy-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(methylthiazol-4-yl)vinyl]-1-oxacyclohexadecane-2,6-dione; (1S,3S,7S,10R,11S,12S,16R)-7,...
参考文献标题:Synthesis of epothilones,intermediates thereto,analogues and uses thereof
文献作者:Bertinato,P.; Danishefsky,S.J.; Su,D.-S.; Kamenecka,T.; Meng,D.F.; Sorensen,E.J.; Savin,K.A.; Chou,T.-C.; Balog,A.(Sloan-Kettering Institute)
参考来源:JP 2001507716; US 6242469; WO 9901124

Patupilone, (-)-Epothilone B, Epothilone B, EPO-906

埃博霉素BChemical Name: (4S,7R,8S,9S,13R,14S,16S)-13,14-Epoxy-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2(E)-(2-methylthiazol-4-yl)vinyl]-1-oxacyclohexadecane-2,6-dione; (1S,3S,7S,10R,11S,12S,16R...
参考文献标题:Method for producing epothilone B and derivs.,and intermediate products for this method
文献作者:Mulzer,J.; 謍ler,E.; Mantoulidis,A.(Schering AG)
参考来源:WO 0023452

Pelitinib, WAY-EKB-569, EKB-569

培利替尼莫立替尼 Chemical Name: N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2(E)-butenamide
CAS No. 257933-82-7, 326894-84-2 (undefined isomer)
项目整合开发状态: Phase...
参考文献标题:Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles.The design of an orally active,irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epi
文献作者:Wissner,A.; Overbeek,E.; Reich,M.F.; Floyd,B.; Johnson,B.D.; Mamuya,N.; Rosfjord,E.C.; Discafani,C.; Davis,R.; Shi,X.; Rabindran,S.K.; Gruber,B.C.; Ye,F.; Hallett,W.A.; Nilakantan,R.; Shen,R.; Wang,Y.-F.; Greenberger,L.M.; Tsou,H.-R.
参考来源:J Med Chem 2003,46(1),49

Donetidine, SK&F-93574

多奈替丁Chemical Name: 5-[(1,2-Dihydro-2-oxo-4-pyridinyl)methyl]-2-[[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]amino]-4(1H)-pyrimidone
CAS No. 99248-32-5, 72716-91-7 (triHCl)
项目整合开...
参考文献标题:Pyrimidine compounds
文献作者:Brown,T.H.; Ife,R.J.(SmithKline Beecham plc)
参考来源:DD 140252; EP 0003677; ES 477667; US 4234588; US 4649141

Domperidone, R-33812, Nauzelin, Motilium

多潘立酮Chemical Name: 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone; 5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-...
参考文献标题:Domperidone
文献作者:Castar,J.
参考来源:Drugs Fut 1977,2(10),661

Domiodol, MG-13608

多米奥醇Chemical Name: 1-[2-(Iodomethyl)-1,3-dioxolan-4-yl]methanol
CAS No. 61869-07-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in two similar ways:1) The cyclization of 1-be...
参考文献标题:
文献作者:Carissimi,M.
参考来源:CA 1064044; DE 2610704; FR 2305979; GB 1487165; JP 76122065

Doramapimod, BIBR-796, BIRB-796 BS, BIRB-0796, BIRB-796

多马莫德Chemical Name: N-[3-tert-Butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]naphthalen-1-yl]urea
CAS No. 285983-48-4
项目整合开发状态: Phase II
项目研究机构: Boehringer Ingelheim...
参考文献标题:Aromatic heterocyclic cpds.as antiinflammatory agents
文献作者:Regan,J.R.; Zhang,L.-H.; Cirillo,P.F.; Hickey,E.R.; Gilmore,T.A.(Boehringer Ingelheim Pharmaceuticals Inc.)
参考来源:EP 1147104; US 6319921; WO 0043384

Ceftazidime, LY-139381, GR-20263, Fortam, Glazidim, Fortum, Modacin, Tazidime, Tazicef, Pentacef, Fortaz, Ceptaz

头孢他啶Chemical Name: (6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)-2(Z)-(1-carboxy-1-methylethyloxyimino)acetamido]-8-oxo-3-(1-pyridiniumylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydra...
参考文献标题:Ceftazidime
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1981,6(10),612

Cefixime, FK-027, CL-284635, FR-17027, Suprax, Oroken, Denvar, Necopen, Tricef, Cephoral, Suprax, Cefspan

头孢克肟Chemical Name: (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7(2)-(Z)-[O-(carboxymethyl)oxime]; 7beta-[2-(2-Aminothiazol-4-yl...
参考文献标题:Starting compounds for 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for their preparation
文献作者:Takaya,T.; Tagasuki,H.; Masugi,T.; Yamanaka,H.; Kawabata,K.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0030630; EP 0123024; EP 0244637; JP 6279452; US 4409214; US 4423213