Domperidone, R-33812, Nauzelin, Motilium
多潘立酮Chemical Name: 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone; 5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS No. 57808-66-9
项目整合开发状态: Launched-1978
项目研究机构: Janssen (Originator), Altana Pharma (Licensee), Esteve (Licensee), Sanofi-Aventis (Licensee)
合成路线:By condensation of 1-(3-chloropropyl)-2-benzimidazolinone (I) with 5-chloro-1-(piperidin-4-yl)-2-benzimidazolinone (II) by means of Na2CO3 and KI in 4-methyl-2-pentanone.
📌 参考资料/链接：
参考文献标题:Domperidone
文献作者:Castar,J.
参考来源:Drugs Fut 1977,2(10),661
📄 详细内容
合成路线:By condensation of 1-(3-chloropropyl)-2-benzimidazolinone (I) with 5-chloro-1-(piperidin-4-yl)-2-benzimidazolinone (II) by means of Na2CO3 and KI in 4-methyl-2-pentanone.
参考文献标题:1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
文献作者:Van Heertum,A.; et al.
参考来源:BE 0844087; FR 2361889; JP 61093183; US 4066772
产品链接: CAS No. 57808-66-9››