Tampramine fumarate, AHR-9377
坦帕明 Chemical Name: N,N-Dimethyl-6-phenyl-11H-pyrido[2,3-b][1,4]benzodiazepine-11-propanamine (E)-butenedioate (1:1); 6-Phenyl-11-[3-(dimethylamino)propyl]-11H-pyrido[2,3-b][1,4]benzodiazepine fumarate
CAS No. 83166-18-1, 83166-17-0 (free base)
项目整合开发状态: Phase I
项目研究机构: Wyeth Consumer Healthcare (Originator)
合成路线:The cyclization of 2-aminobenzophenone (I) with 3-amino-2-chloropyridine (II) by means of NaOH in methylene chloride-water gives 6-phenyl-11H-[2,3-b][1,4]benzodiazepine (III),which is then condensed with (3-chloropropyl)dimethylamine by means of NaH in hot DMF,followed by a treatment with fumaric acid in isopropanol.
📌 参考资料/链接：
参考文献标题:Pyridol [1,4] benzodiazepines phenyl-substituees et leurs intermediares,utiles comme medicaments antidepresseurs
文献作者:Taylor,C.R.Jr.(A.H.Robins Co.Inc.)
参考来源:BE 0891666; FR 2515183; JP 58065290
📄 详细内容
合成路线:The cyclization of 2-aminobenzophenone (I) with 3-amino-2-chloropyridine (II) by means of NaOH in methylene chloride-water gives 6-phenyl-11H-[2,3-b][1,4]benzodiazepine (III),which is then condensed with (3-chloropropyl)dimethylamine by means of NaH in hot DMF,followed by a treatment with fumaric acid in isopropanol.
参考文献标题:AHR-9377
文献作者:Serradell,M.N.; Castar,J.; Souto,M.E.
参考来源:Drugs Fut 1984,9(3),163
产品链接: CAS No. 83166-18-1›› 产品链接: CAS No.83166-17-0››