合成路线:It can be prepared in two similar ways:1) The cyclization of 1-benzylglycerol (I) with iodoacetaldehyde (II) by means of sulfosalicylic acid at 100 C gives 2-iodomethyl-4-benzyloxymethyl-1,3-dioxolane (III),which is debenzylated by hydrogenation with H2 over Pd/C in methanol (1).2) The cyclization of 1-benzylglycerol (I) with bromoacetaldehyde (IV) with sulfosalicylic acid at 100 C yields 2-bromomethyl-4-benzyloxymethyl-1,3-dioxolane (V),which is debenzylated by hydrogenation with H2 over Pd/C in methanol affording 2-bromomethyl-4-hydroxymethyl-1,3-dioxolane (VI) (1).Finally this compound is treated at 130 C in a pressure vessel (1,2).
参考文献标题:Domiodol
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; De Angelis,L.
参考来源:Drugs Fut 1980,5(5),236
合成路线:It can be prepared in two similar ways:1) The cyclization of 1-benzylglycerol (I) with iodoacetaldehyde (II) by means of sulfosalicylic acid at 100 C gives 2-iodomethyl-4-benzyloxymethyl-1,3-dioxolane (III),which is debenzylated by hydrogenation with H2 over Pd/C in methanol (1).2) The cyclization of 1-benzylglycerol (I) with bromoacetaldehyde (IV) with sulfosalicylic acid at 100 C yields 2-bromomethyl-4-benzyloxymethyl-1,3-dioxolane (V),which is debenzylated by hydrogenation with H2 over Pd/C in methanol affording 2-bromomethyl-4-hydroxymethyl-1,3-dioxolane (VI) (1).Finally this compound is treated at 130 C in a pressure vessel (1,2).
参考文献标题:Preparazione e studio farmacotossicologico di un novo preparato iododerivato ad attivita mucolitica
文献作者:Cantarelli,G.; et al.
参考来源:II Farmaco (ed.sc.) 1979,34393
产品链接: CAS No. 61869-07-6››