项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Cefcamate pivoxil hydrochloride, Cefcapene pivoxil hydrochloride, S-1108, Flomox, Flumax

头孢卡品酯Chemical Name: [6R-[6alpha,7beta(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl...
参考文献标题:Alkenamidocephalosporin esters
文献作者:Hamashima,Y.; Ishikura,K.; Minami,K.; Kubota,T.; Yoshida,T.(Shionogi & Co.Ltd.)
参考来源:BE 0904517; CH 669600; DE 3610581; ES 8800237; ES 8801922; FR 2579597; GB 2173194; JP 1987000089; US 4731361

Cefcanel daloxate hydrochloride, KY-109

头孢卡奈达酯 Chemical Name: (6R,7R)-7beta-[2(R)-(S-Alanyloxy)-2-phenylacetamido]-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; (5-Met...
参考文献标题:Cephalosporin cpds.
文献作者:Nishizawa,S.; Tamaki,S.; Kakeya,N.; Kitao,K.(Kyoto Pharmaceutical Industries,Ltd.)
参考来源:WO 8505360

Ceftizoxime

头孢唑肟Chemical Name: (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-cephem-4-carboxylic acid
CAS No. 68401-81-0
项目整合开发状态: Not Determined
项目研究机构:
合成路线:By condesation of ...
参考文献标题:Ceftizoxime
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Sweetman,A.J.
参考来源:Drugs Fut 1980,5(5),226

Ceftizoxime alapivoxil, AS-924, KY-020

头孢唑肟丙匹酯Chemical Name: (6R,7R)-7-[2-(2-L-Alanylaminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-cephem-4-carboxylic acid pivaloyloxymethyl ester
CAS No. 135821-54-4
项目整合开发状态: Pre-Registered 参考文献标题:Cephalosporin cpds.and production thereof
文献作者:Muro,H.; Kasai,M.; Hatano,s.; Nishimura,K.-I.; Nishizawa,S.; Kakeya,N.(Kyoto Pharmaceutical Industries,Ltd.)
参考来源:EP 0497978; JP 1991204883; US 5389625; WO 9106549

Cefbuperazone sodium, T 1982, BMY-25182, Tomiporan, Keiperazon

头孢拉宗钠头孢拉宗 Chemical Name: (6R,7S)-7-[(2R,3S)-2-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-3-hydroxybutyramido]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oc...
参考文献标题:Novel 7alpha-methoxycephalosporins and process for producing the same
文献作者:Saikawa,I.; et al.(Toyama Chemical Co.,Ltd.)
参考来源:FR 2455051; GB 2048241; JP 80141.491; JP 8125188; US 4263292

PPI-0903, TAK-599

头孢洛林酯内盐 Chemical Name: (6R,7R)-7-[(Z)-2-(Ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate acetate
CAS ...
参考文献标题:TAK-599,a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis,physicochemical and pharmacological properties
文献作者:Ishikawa,T.; Matsunaga,N.; Tawada,H.; et al.
参考来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002,San Diego) 2002,Abst F-332

Cefteram pivoxil, Ro-19-5248, T-2588, Tomiron

头孢特仑新戊酯Chemical Name: [6R-(6alpha,7beta)]-7-[2-(2-Amino-4-thiazolyl)-2(Z)-(methoxyimino)acetamido]-3-(5-methyl-2H-tetrazol-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2...
参考文献标题:Cephalosporins
文献作者:Hirakawa,T.; Imaizumi,H.; Inaba,T.; Konishi,Y.; Narita,H.; Sadaki,H.; Saikawa,I.; Tai,M.; Taki,H.; Watanabe,Y.(Toyama Chemical Co.,Ltd.)
参考来源:AU 8549860; AU 8549863; DE 3137854; US 4489072

Sulcephalosporin, Cefsulodin sodium, SCE-129, CGP-7174/E, Abbott-46811, Tilmapor, Takesulin, Pseudomonil, Pseudocef, Monaspor

头孢磺啶钠头孢磺啶 Chemical Name: 4-Carbamoyl-1-[[(6R,7R)-2-carboxy-8-oxo-7-[(2R)-2-phenyl-2-sulfoacetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium hydroxide,inner salt,sodium salt; [6R-[6...
参考文献标题:Cefsulodin
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.; Sweetman,A.J.
参考来源:Drugs Fut 1980,5(2),67

Cefazedone

头孢西酮Chemical Name: (6R,7R)-7-[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetamido]-3-(5-methyl-1,3,4-thiadiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No. ...
参考文献标题:
文献作者:Gericke,R.; et al.
参考来源:DE 2345402

Quazepam, Sch-161, Sch-16134, Oniria, Doral, Quazium, Selepam, Prosedar, Dormalin, Cetrane

夸西泮Chemical Name: 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
CAS No. 36735-22-5
项目整合开发状态: Launched-1985
项目研究机构: Schering-Plough (Originat...
参考文献标题:Quazepam
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1978,3(2),139