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项目整合精选>>>Sulcephalosporin, Cefsulodin sodium, SCE-129, CGP-7174/E, Abbott-46811, Tilmapor, Takesulin, Pseudomonil, Pseudocef, Monaspor
Sulcephalosporin, Cefsulodin sodium, SCE-129, CGP-7174/E, Abbott-46811, Tilmapor, Takesulin, Pseudomonil, Pseudocef, Monaspor
头孢磺啶钠 头孢磺啶 Chemical Name: 4-Carbamoyl-1-[[(6R,7R)-2-carboxy-8-oxo-7-[(2R)-2-phenyl-2-sulfoacetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium hydroxide,inner salt,sodium salt; [6R-[6alpha,7beta(R*)]]-4-(Aminocarbonyl)-1,2-[[2-carboxy-8-oxo-7-[(phenylsulfoacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium hydroxide,inner salt,sodium salt
CAS No. 52152-93-9, 62587-73-9 (free acid)
项目整合开发状态: Launched-1981
项目研究机构: Novartis (Originator), Takeda (Originator)
合成路线:The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III),which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.
📌 参考资料/链接：
参考文献标题:Cefsulodin
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.; Sweetman,A.J.
参考来源:Drugs Fut 1980,5(2),67
📄 详细内容
合成路线:The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III),which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.
参考文献标题:Semisynthetic beta-lactam antibiotics.6.Sulfocephalosporins and their antipseudomonal activities
文献作者:Nomura,H.; Fugono,T.; Hitaka,T.; Minami,I.; Azuma,T.; Morimoto,S.; Masuda,T.
参考来源:J Med Chem 1974,17(12),1312-15
合成路线:The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III),which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.
参考文献标题:Cephalosporin compounds
文献作者:Morimoto,S.; et al.
参考来源:DE 2234280; ES 404745; FR 2146313; NL 7209811
合成路线:The reaction of 7-aminocephalosporanic acid (I) with alpha-sulfophenylacetyl chloride (II) by means of NaOH and NaHCO3 in ether gives 7-(alpha-sulfophenylacetamido)cephalosporanic acid (III),which is then condensed with isonicotinamide (IV) by means of KSCN and pyridine in water.
参考文献标题:Semisynthetic beta-lactams antibiotics.VII.New semisynthetic cephalosporins derived from alpha-sulfophenylacetic acid
文献作者:Nomura,H.; et al.
参考来源:Heterocycles 1974,2(1),67-72
产品链接: CAS No. 52152-93-9›› 产品链接: CAS No.62587-73-9››