Cefazedone
头孢西酮Chemical Name: (6R,7R)-7-[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetamido]-3-(5-methyl-1,3,4-thiadiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No. 56187-47-4
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reaction of 7-aminocephalosporanic acid tert-butyl ester (I) with 3,5-dichloro-4-pyridone-1-acetic acid (II) by means of dicyclohexylcarbodiimide in CH2Cl2 gives 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid tert-butyl ester (III),which is hydrolyzed with trifluoroacetic acid yielding the corresponding free acid (IV).Finally this acid is condensed with 5-methyl-1,3,4-thiadiazol-2-thiol (V) by means of NaHCO3 in a hot mixture of water and acetone.
📌 参考资料/链接：
参考文献标题:
文献作者:Gericke,R.; et al.
参考来源:DE 2345402
📄 详细内容
合成路线:The reaction of 7-aminocephalosporanic acid tert-butyl ester (I) with 3,5-dichloro-4-pyridone-1-acetic acid (II) by means of dicyclohexylcarbodiimide in CH2Cl2 gives 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid tert-butyl ester (III),which is hydrolyzed with trifluoroacetic acid yielding the corresponding free acid (IV).Finally this acid is condensed with 5-methyl-1,3,4-thiadiazol-2-thiol (V) by means of NaHCO3 in a hot mixture of water and acetone.
参考文献标题:Cefazedone
文献作者:Castar,J.; Prous,J.R.; Blancafort,P.
参考来源:Drugs Fut 1977,2(11),717
产品链接: CAS No. 56187-47-4››