Cefcamate pivoxil hydrochloride, Cefcapene pivoxil hydrochloride, S-1108, Flomox, Flumax

头孢卡品酯Chemical Name: [6R-[6alpha,7beta(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester hydrochloride; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylic acid pivaloyloxymethyl ester hydrochloride
CAS No. 105889-45-0 (free base), 105889-46-1 (mono(trifluoroacetate) salt)
项目整合开发状态: Launched-1997
项目研究机构: Shionogi (Originator)
合成路线:The condensation of 2(Z)-[2-(tert-butoxycarbonylamino)thiazol-4-yl]-2-pentenoic acid (I) with 7-amino-3-(carbamoyloxymethyl)-3-cephem-4-carboxylic acid pivaloylmethyl ester (II) by means of POCl3 and triethylamine (or oxalyl chloride and picoline) gives the corresponding amide (III),which is then deprotected with trifluoroacetic acid and anisole in dichloromethane.